摘要
越来越多的证据表明环氧二十碳三烯酸(epoxyeicosatrienoic acids,EETs)能够通过多种作用机制在组织器官缺血/再灌注(ischemia/reperfusion,I/R)损伤中发挥保护性作用,其中线粒体途径在这些作用机制中有着重要的地位。然而作为I/R损伤防治的重要靶点,线粒体途径在EETs介导的I/R损伤保护机制中却未得到很深入的探讨。本文就线粒体K+通道、线粒体通透性转换孔、线粒体促凋亡蛋白以及线粒体结构完整性在EETs减轻I/R损伤中所起的作用作一综述,为以后更深层次的研究提供理论基础,同时这对于寻找I/R新的防治方式和靶点、保护重要组织器官、改善患者的病情及预后都有着重要意义。
Increasing evidence suggests that epoxyeicosatrienoic acids( EETs) play a protective role in tissue and organ ischemia/reperfusion( I/R) injury through a variety of mechanisms,and the mitochondrial pathway plays an important role in these mechanisms. However,as an important target for I/R injury prevention and treatment,the mitochondrial pathway has not been explored in depth for EET-mediated protective mechanisms in I/R injury. This review summarizes the role of mitochondrial K+channels,mitochondrial permeability transition pores,mitochondrial proapoptotic proteins,and mitochondrial structural integrity in EET-mediated reductions of I/R injury,providing a theoretical basis for further research. This is of great significance for preventing and treating I/R injury of organs,and improving the prognosis of this disease.
作者
叶永才
陈哲璇
李想
谭伟江
杨丰华
张良清
YE Yongcai;CHEN Zhexuan;LI Xiang;TAN Weijiang;YANG Fenghua;ZHANG Liangqing(Department of Anesthesiology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China;Guangdong Laboratory Animals Monitoring Institute,Guangdong Key Laboratory for Laboratory Animals,Guangzhou 510633)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第11期105-110,共6页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(81470405)
广东省实验动物重点实验室(2017B030314171)
广东省科技专项(2017B020231001,2017A020215076)
广州市计划项目(201707010376)
关键词
环氧二十碳三烯酸
缺血/再灌注损伤
线粒体
epoxyeicosatrienoic acids(EETs)
ischemia/reperfusion(I/R) injury
mitochondria
作者简介
叶永才(1993-),男,硕士研究生,研究方向:围手术期心血管保护。E-mail:625142023@qq.com;通信作者:杨丰华(1970-),女,副研究员,研究方向:心血管生物学与心血管疾病动物模型的构建。E-mail:fenghua.yang@gdlami.com;通信作者:张良清(1970-),男,副教授,博士生导师,研究方向:围手术期器官保护。E-mail:zhanglq1970@163.com。
