摘要
目的循环肿瘤细胞(circulating tumor cells,CTCs)检测是一种新兴的微创液体活检技术,有助于肿瘤的早期诊断和治疗过程中的疾病监测。本研究通过监测晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者行大分割调强放疗前后CTCs的动态变化,探讨CTCs与患者临床特征及近期疗效的相关性。方法用膜过滤分离肿瘤细胞技术(isolation by size of epithelial tumor cells,ISET)检测2016-06-12-2017-12-18苏州大学附属常州肿瘤医院23例Ⅲ~Ⅳ期NSCLC患者大分割调强放疗前后CTCs,探讨放疗前后CTCs的数量及变化与临床特征及近期疗效的关联性。结果放疗前CTCs阳性率与T分期(P=0.013)、N分期(P=0.036)有关联,放疗前CTCs阳性率与患者无进展生存期(progress free survival,PFS)有关联(P=0.029)。放疗前后CTCs变化与近期疗效(P=0.033)有关联,差异均有统计学意义。结论放疗后CTCs下降的患者可以获得较好的近期疗效,放疗前CTCs可以作为晚期NSCLC患者PFS的一项预测指标。
OBJECTIVE Circulating tumor cell detection is a new minimally invasive liquid biopsy technique,which is helpful for early diagnosis and disease monitoring during treatment.This report was to monitor the dynamic changes of circulating tumor cells in advanced non-small cell lung cancer patients before and after hypofractionated intensity modulated radiation therapy,and to explore the correlation of CTCs with clinical characteristics and the recent curative effect.METHODS The ISET technique had been applied to detect the CTCs in 23 stageⅢ-Ⅳ NSCLC patients from June 122016 to December 18 2017 in Changzhou Tumor Hospital before and after hypofractionated intensity modulated radiation therapy,and the correlation between CTCs with clinical characteristics and the recent curative effect of patients had been explored.RESULTS The positive rate of CTCs before radiotherapy was closely associated with the T stage,lymph node metastasis with p-value of 0.013 and 0.036 respectively.It was correlated with the progress free survival of patients with ap-value of 0.029.The change of CTCs after radiotherapy was significantly correlated with the recent curative effect with ap-value of 0.033.CONCLUSIONS Patients with declined CTCs after radiotherapy would receive better recent curative effect.CTCs could be used as a predictive indicator of PFS of advanced NSCLC patients treated with hypofractionated intensity modulated radiation.
作者
刘俊
卢绪菁
刘永萍
周健
丁玉琼
张磊
LIU Jun;LUXu-jing;LIU Yong-ping;ZHOU Jian;DING Yu-qiong;ZHANG Lei(Department of Radiotion Oncology,Third Affiliated Hospital of Soochozv University,Changzhou 213001,P.R.China;Cancer Center,Changzhou Tumor Hospital Affiliated to Soochoiv University,Changzhou 213001,P.R.China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2019年第18期1367-1372,共6页
Chinese Journal of Cancer Prevention and Treatment
关键词
循环肿瘤细胞
非小细胞肺癌
大分割调强放疗
无疾病进展
non-small cell lung cancer
circulating tumor cells
hypofractionated intensity modulated radiation therapy
progress free survival
作者简介
第一作者简介:刘俊,女,回族,江苏常州人,主治医师,主要从事胸部肿瘤放疗的研究工作。Tel:86-519-69807628,E-mail:568956095@qq.com;通讯作者简介:刘永萍,女,陕西榆林人,博士,主任医师,主要从事肿瘤个体化诊疗研究工作。Tel:86—519—69803591,E-mail:liuyongping026@126.com。
