摘要
白藜芦醇是一种具有广泛生物活性的茋类化合物。为了寻找活性较强的新型分子,以白藜芦醇为原料出发,经Vilsmeier甲酰化和Knoevenagel缩合,合成了3个未见文献报道的香豆素类白藜芦醇衍生物(E)-7-羟基-5-(4-羟基苯乙烯基)香豆素衍生物(3a^3c),其结构经1H NMR、13C NMR和HRMS确证。抗炎和抗氧化活性研究发现,化合物3a具有与地塞米松相当的抗炎活性,并对超氧阴离子和羟基自由基有较强的清除作用,可做进一步研究。
Resveratrol exhibits a broad range of biological activities. In order to study new biological agents,three novel( E)-7-hydroxy-5-( 4-hydroxystyryl) coumarin derivatives( 3 a ~ 3 c) were designed and synthesized starting from resveratrol by Vilsmeier formylation and Knoevenagel condensation. Their structures were characterized by 1H NMR,13C NMR and HRMS,and the anti-inflammatory and antioxidant activities were evaluated in vitro. The results demonstrated that the anti-inflammatory potency of compound 3 a is almost equal to that of the positive control dexamethasone,and it has good superoxide anion and hydroxyl free radical scavenging effect.
作者
李敏欣
黎勇坤
刘蓓
尹芃程
高慧
毛泽伟
Li Minxin;Li Yongkun;Liu Bei;Yin Pengcheng;Gao Hui;Mao Zewei(College of Pharmaceutical Science,Yunnan University of Chinese Medicine,Kunming 650500)
出处
《化学通报》
CAS
CSCD
北大核心
2019年第11期1043-1046,共4页
Chemistry
基金
国家自然科学基金项目(81560620)
云南省科学技术厅-云南中医药大学应用基础研究联合专项(2017FF117(-023))
云南中医药大学大学生创新创业训练计划项目(2018008)资助
关键词
白藜芦醇
香豆素
抗炎活性
抗氧化活性
Resveratrol
Coumarin
Anti-inflammatory activity
Antioxidant activity
作者简介
联系人:毛泽伟,男,副教授。E-mail:maozw@ynutcm.edu.cn.
