摘要
目的观察加味参苓白术散治疗腹泻型肠易激综合征(D-IBS)的临床疗效,初探肠粘膜肥大细胞(MC)和血浆5-羟色胺(5-HT)在IBS发病机制中可能的作用。方法收集脾胃虚弱型D-IBS患者60例、健康志愿者30例。将60例患者随机分成2组,治疗组给予加味参苓白术散治疗,对照组给予匹维溴铵治疗,疗程4周,观察治疗的总有效率,比较两组患者治疗前后MC数目、5-HT水平变化,同时与健康组比较。结果治疗组总有效率优于对照组,治疗前后两组患者的MC数目和5-HT水平均有所下降,比较差异有统计学意义(P<0.05)。治疗前两组患者的MC数目和5-HT水平较健康组明显升高,比较差异有统计学意义(P<0.05)。结论加味参苓白术散治疗脾胃虚弱型D-IBS取得良好的临床疗效,MC、5-TH可能均参与D-IBS发病机制的重要环节。
Objective To observe clinical effect of modified Shenling atractylodes macrocephala powder on diarrhea-predominant irritable bowel syndrome(D-IBS), and explore possible role of intestinal mucosal mast cells(MC) and plasma 5-hydroxytryptamine(5-HT) in pathogenesis of IBS. Methods Collect 60 cases spleen-stomach weakness type D-IBS patients and 30 cases healthy volunteers. Divide them into two groups randomly. Treatment group was treated with modified Shenling atractylodes macrocephala powder and control group with pivobromide for 4 weeks. Observe total effective rate, and compare MC numbers and 5-HT level between two groups before and after treatment again healthy group. Results Total effective rate of treatment group was better than that of control group. MC numbers and 5-HT level in two groups decreased before and after treatment, and difference was statistically significant(P<0.05). MC numbers and 5-HT level in two groups before treatment were significantly higher than healthy group(P<0.05). Conclusion Modified shenling atractylodes macrocephala powder has good clinical effect in treatment of D-IBS with spleen and stomach weakness. MC and 5-TH may play an important role in pathogenesis links of D-IBS.
作者
张婷婷
周文博
黄泽辉
ZHANG Ting-ting;ZHOU Wen-bo;HUANG Ze-hui(Zhangzhou City Traditional Chinese Hospital,Zhangzhou,Fujian,363000)
出处
《智慧健康》
2019年第30期64-65,148,共3页
Smart Healthcare
基金
2016年福建省卫生计生青年科研课题（项目编号：2016-2-43）
关键词
加味参苓白术散
腹泻型肠激综合征
临床疗效
MC数目
5-HT水平
Modified Shenling atractylodes macrocephala powder
Diarrhea-type irritable bowel syndrome
Clinical effect
MC Number
5-HT Level
作者简介
张婷婷(1983-),女,汉,福建平和,研究生,主治医师,中西医结合消化疾病;通信作者:周文博(1970-),男,汉,福建平和,本科,副主任医师,中西医结合消化疾病;黄泽辉(1982-),男,汉,福建龙海,研究生,主治医师,中西医结合消化疾病。
