摘要
目的分析无症状性颅内动脉狭窄(AIAS)患者的临床特征,探讨与脑卒中相关的危险因素并提出干预措施。方法选取2016年1月~2017年12月在首都医科大学附属北京天坛医院神经内科诊断为AIAS的人群122例为研究对象,随访1年。将随访期间出现脑卒中的患者纳入阳性组(n=21),未出现脑卒中的患者纳入阴性组(n=101)。比较两组患者的临床特征,分析AIAS患者发生脑卒中的危险因素。结果阳性组有高血压、饮酒、吸烟者占比高于阴性组,三酰甘油(TG)的含量高于阴性组,miRNA-223相对表达量低于阴性组,差异均有统计学意义(P<0.05)。两组患者体重指数、糖尿病史、白蛋白、同型半胱氨酸、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇、血管狭窄程度、血管病变支数比较,差异均无统计学意义(P>0.05)。Logistic回归分析发现,吸烟、饮酒、TG含量≥1.98 mmol/L、miRNA-223相对表达量≤0.56均是AIAS患者发生脑卒中的高危因素(P<0.05)。在预测AIAS患者是否发生脑卒中方面,使用miRNA-223相对表达量好于TG含量。结论吸烟、饮酒、TG含量过高、miRNA-223相对表达量低是AIAS患者发展为缺血性脑卒中的高危因素,需加强人群的健康教育、戒烟戒酒、健康饮食,定期做好相关指标检查,必要时给予药物治疗。
Objective To analyze the clinical characteristics of asymptomatic intracranial artery stenosis(AIAS)patients and identify the risk factors associated with stroke and propose intervention measures.Methods From January 2016 to December 2017,122 patients who diagnosed with AIAS in Beijing Tiantan Hospital,Capital Medical University,were selected as study subjects,follow-up of 1-year.During this period,stroke patients were included in the positive group(n=21)and patients without stroke were included in the negative group(n=101).The clinical characteristics of two groups were compared,the risk factors of stroke in AIAS patients were analyzed.Results The propotion of hypertension,drinking and smoking in the positive group was higher than those in the negative group,the content of triacylglycerol(TG)was higher than that in the negative group,the relative expression of miRNA-223 was lower than that in the negative group,the differences were statistically significant(P<0.05).There were no significant differences in body mass index,history of diabetes,albumin,homocysteine,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,total cholesterol,degree of vascular stenosis and number of lesion vessels between the two groups(P>0.05).Logistic regression analysis showed that smoking,drinking,TG≥1.98 mmol/L and relative expression of miRNA-223≤0.56 were high risk factors for stroke in AIAS patients(P<0.05).In the prediction of stroke in AIAS patients,the relative expression of miRNA-223 had higher prediction value than the content of TG.Conclusion Smoking,drinking,TG≥1.98 mmol/L and relative expression of microRNA-223≤0.56 are high risk factors for AIAS patients to develop ischemic stroke.Health education,quitting smoking and alcohol,healthy diet,regularly checking relevant indicators,necessary drug treatment were required in AIAS patients.
作者
周雪姣
邓永梅
张倩
ZHOU Xuejiao;DENG Yongmei;ZHANG Qian(Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)
出处
《中国医药导报》
CAS
2019年第29期80-83,共4页
China Medical Herald
基金
国家自然科学基金资助项目（81501001）
作者简介
周雪姣(1987-),女,首都医科大学附属北京天坛医院神经内科护士长,研究方向:缺血性卒中、出血性卒中、脑小血管病相关神经内科疾病的护理。
