摘要
支气管哮喘(哮喘)是一种变态反应性疾病,其主要特征为气道高反应性和慢性气道炎症。8-羟基鸟嘌呤DNA糖苷酶(OGG1)是一个碱基切除DNA修复酶,OGG1可能在哮喘发作期间影响氧化应激和促炎因子的表达水平。OGG1可能直接或间接的在哮喘发病机制中发挥重要作用。本文主要介绍OGG1在哮喘发病中的作用及其可能机制,为寻找哮喘治疗新靶点奠定基础。
Bronchial asthma(asthma)is an allergic disease,which is involved with airway hyperresponsiveness and chronic airway inflammation.8-oxoguanine DNA glycosylase(OGG1)is a base-cleaving DNA repair enzyme that may affect the expression levels of oxidative stress and pro-inflammatory factors during asthma attacks.OGG1 may play an important role directly or indirectly in the pathogenesis of asthma.This paper reviews the role of OGG1 in the pathogenesis of asthma and its possible mechanisms,laying the foundation for the search for new targets for asthma treatment.
作者
魏冲
Wei Chong(Department of Respiratory and Critical Care Medicine,the First People′Hospital of Neijiang,Neijiang 641000,China)
出处
《国际呼吸杂志》
2019年第20期1558-1561,共4页
International Journal of Respiration
作者简介
通信作者:魏冲,Email:418031723@qq.com。
