摘要
骨骼肌中成肌细胞作为肌源性祖细胞具有自我更新和生成新的肌纤维的能力,而氧气水平对调节成肌细胞的肌生成能力至关重要。这篇综述中描述了低氧状态下细胞的分子调控,氧水平对成肌细胞在肌生成中的影响和骨骼肌成肌细胞增殖和分化的转录调节。本文还概述了多种信号通路在分子调控中的机制,其中Notch,Wnt信号通路是依赖于低氧诱导因子HIF-1α介导的机制;PI3K-Akt-mTOR、p38 MAPK、p53信号传导则是独立于HIF-1α在低氧下调节成肌分化的途径。因此,深入研究和进一步揭示机制中涉及的信号通路为治疗低氧对骨骼肌损伤性的疾病提供证据和参考。
As myogenic progenitor cells,skeletal muscle myoblasts,can self-renew and generate new muscle fibers,and oxygen levels are critical for regulating myogenesis of myoblasts.This review describes the molecular regulation of cells under hypoxic conditions,the effects of oxygen levels on myoblasts in myogenesis,and the transcriptional regulation of skeletal myoblast proliferation and differentiation.This paper also outlines the mechanisms of various signaling pathways in molecular regulation,in which the hypoxia-inducible factor HIF-1αmediates Notch and Wnt signaling pathways;whereas PI3 K-Akt-mTOR,p38 MAPK,and p53 signaling regulate myogenic differentiation under hypoxia independent of HIF-1α.Therefore,an in-depth study and further revealing the signaling pathways involved in the mechanism provide evidence and reference for the treatment of skeletal muscle injury diseases caused by hypoxia.
作者
张维华
於丽明
韩欣欣
刘月华
ZHANG Wei-Hua;YU Li-Ming;HAN Xin-Xin;LIU Yue-Hua(Shanghai Stomatological Hospital,Fudan University,Shanghai 200001,China;Oral Biomedical Engineering Laboratory,Shanghai Stomatological Hospital,Shanghai 200001,China)
出处
《生理科学进展》
CAS
北大核心
2019年第5期326-332,共7页
Progress in Physiological Sciences
基金
国家自然基金面上项目(81771109)
上海市卫生和计划生育委员会重点项目(201640023)
上海市科委创新行动项目-实验动物模型(15140903500)资助课题
关键词
低氧
骨骼肌
成肌细胞
成肌分化
信号通路
hypoxia
skeletal muscle
myoblasts
myogenic differentiation
signaling pathway
作者简介
通讯作者:刘月华,liuyuehua@fudan.edu.cn。
