摘要
目的探讨药学服务对老年慢性阻塞性肺疾病(COPD)稳定期患者用药依从性及药品不良反应(ADR)的影响。方法选取医院2016年5月至2018年6月收治的老年COPD稳定期患者123例,按随机数字表法分为试验组(62例)与对照组(61例)。两组均予常规治疗,对照组患者进行常规用药指导,研究组患者进行临床药学干预,均持续6个月。结果试验组的用药依从率为95.16%,显著高于对照组的83.61%(P<0.05);与干预前比较,两组患者干预后的第1秒用力呼气容积(FEV1)、FEV1占预计值的百分比(FEV1%)及FEV1/FVC水平均明显升高,白细胞介素8(IL-8)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平均显著降低,且试验组上述指标改善程度均显著优于对照组(P<0.05);试验组ADR发生率为3.22%,显著低于对照组的14.75%(P<0.05)。结论药学服务能有效提高老年COPD稳定期患者的用药依从性,减少ADR,改善肺功能。
Objective To investigate the effect of pharmaceutical care on drug compliance and adverse drug reaction(ADR)in elderly patients with chronic obstructive pulmonary disease(COPD)at stable stage.Methods Totally 123 elderly patients with COPD at stable stage admitted to our hospital from May 2016 to June 2018 were selected and divided into the treatment group(n=62)and the control group(n=61)by the random number table method.The patients in the two groups received routine COPD stabilization treatment,the patients in the control group were given routine medication guidance,while the patients in the treatment group were given clinical pharmacy intervention.Both groups were treated for 6 months.Results The drug compliance of the treatment group was 95.16%,which was significantly higher than 83.61%of the control group(P<0.05).Compared with those before intervention,the levels of forced expiratory volume in one second(FEV1),FEV1%and FEV1/forced vital capacity(FVC)in the two groups were significantly increased,while the levels of interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the two groups were significantly decreased,and the improvement of the above indexes in the treatment group was significantly better than that in the control group(P<0.05).During the treatment,the incidence of ADR in the treatment group was 3.22%,which was significantly lower than 14.75%in the control group(P<0.05).Conclusion Pharmaceutical care can effectively improve drug compliance,reduce ADR and improve pulmonary function in elderly patients with COPD at stable stage.
作者
陈小燕
倪春艳
周琳
杨彧
任洁
CHEN Xiaoyan;NI Chunyan;ZHOU Lin;YANG Yu;REN Jie(The First People's Hospital of Changzhou,The Third Affiliated Hospital of Soochow University,Changzhou,Jiangsu,China 213000)
出处
《中国药业》
CAS
2019年第22期74-76,共3页
China Pharmaceuticals
基金
江苏省自然科学基金[BK2016133]
关键词
慢性阻塞性肺疾病
稳定期
老年
用药依从性
药品不良反应
药学服务
chronic obstructive pulmonary disease
stable stage
elderly
drug compliance
adverse drug reactions
pharmaceutical care
作者简介
第一作者:陈小燕,女,大学本科,主管药师,研究方向为药学,电子信箱:jms014@163.com。
