摘要
目的:探讨中老年原发性高血压(essential hypertension,EH)不同血压水平与血清催产素(oxytocin,OT)、胰岛素抵抗(insulin resistance,IR)的关系。方法:选取门诊体检健康者和EH患者作为研究对象,年龄≥45岁,分为以下四组:①体检健康组(正常对照组)50例;②血压1级组25例;③血压2级组22例;④血压3级组3例。观测四组年龄、腰臀比(WHR)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、胰岛素(FINS)、胰岛素释放指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、血清OT等指标。结果:正常对照组、EH1级组、EH2级组、EH3级组组间临血清OT、HOMA-IR与WHR、SBP、DBP、FPG、FINS、HOMA-β存在相关性(P≤0.001),血清OT与HOMA-IR呈负相关(r=-0.744),Logistic逐步回归分析显示,FPG、FINS、HOMA-IR、OT是EH的主要影响因素(P<0.05)。结论:中老年EH患者的血压水平与血清OT、IR具有相关性,建议在临床中加强该两项指标的监测。
Objective To explore the relationship between different blood pressure levels and serum oxytocin insulin resistance in middle-aged and elderly patients with essential hypertension;Method The subjects were healthy persons and EH patients aged over 45 years.They were divided into four groups:①Physical examination group(normal control group),50 cases;②Blood pressure level 1 group,25 cases;③Blood pressure level 2 group,22 cases;④Blood pressure level 3 group,3 cases.Age,waist-hip ratio(WHR),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FPG),insulin(FINS),insulin release were observed.Radiation index(HOMA-beta),insulin resistance index(HOMA-IR),serum OT and other indicators;Results The correlation analysis showed that serum OT,HOMA-IR were correlated with WHR,SBP,DBP,FPG,FINS,HOMA-beta(P<0.001).Serum OT was negatively correlated with HOMA-IR(r=-0.744).Logistic stepwise regression analysis showed that FPG,FINS,HOMA-IR and OT were EH.Main influencing factors(P<0.05).Conclusion The blood pressure level of middle-aged and old EH patients is correlated with serum OT and IR.It is suggested to strengthen the monitoring of these two indicators in clinical practice.
作者
袁娟
卢薇
王青
余红岚
赵素云
李海英
喻杰
杨睿
YUAN Juan;LU Wei;WANG Qing(Department of Endocrinology,The First People′s Hospital of Guiyang City,Guiyang,550003,China)
出处
《吉林医学》
CAS
2019年第11期2457-2459,共3页
Jilin Medical Journal
基金
2016年贵阳市卫生计生委高层次创新型青年卫生人才培训计划项目[项目编号:023]
关键词
原发性高血压
催产素
胰岛素抵抗
Essential hypertension
Oxytocin
Insulin resistance
