摘要
近年来,急性感染性疾病的新型生物学标志物不断被发现,其中钙结合蛋白S100A12主要在人外周血细胞中表达,是一种炎性反应蛋白,也是钙结合蛋白S100家族的重要成员。钙结合蛋白S100A12检测方法简单、方便、快捷,在急性感染性疾病尤其是败血症、脓毒症、细菌性肺炎的鉴别诊断、严重程度评估、治疗等方面具有较高的临床应用价值,可作为急性感染性疾病的新型生物学标志物。本文主要综述了钙结合蛋白S100A12在急性感染性疾病中的应用价值,以期为提高临床急性感染性疾病诊治水平提供参考。
Novel biomarkers of acute infectious diseases are continuously found in recent years,thereinto calcium binding protein S100A12 is one kind of inflammatory response proteins,which mainly exist in the human peripheral blood cells and being an important member of calcium binding protein S100 family.Detection method of calcium binding protein S100A12 is simple,convenient and fast,moreover calcium binding protein S100A12 has relatively high application value in the differential diagnosis,severity assessment and treatment of acute infectious diseases especially in septicemia,sepsis and bacterial pneumonia,which may be one of novel biomarkers of acute infectious diseases.This paper mainly reviewed the application value of calcium binding protein S100A12 in acute infectious diseases,in order to improve the clinical diagnostic and therapeutic level.
作者
周晓莲
王雪
李多
ZHOU Xiaolian;WANG Xue;LI Duo(The Second Department of Pulmonary and Critical Care Medicine,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)
出处
《实用心脑肺血管病杂志》
2019年第9期9-13,共5页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
作者简介
通信作者:李多,E-mail:sclzliduo@163.com。
