摘要
目的采用数据挖掘方法分析明清吴门医家医籍便秘处方用药特色,为当代临床便秘治疗提供参考.方法检索南京中医药大学图书馆古籍文献数据库中明清吴门医家便秘处方,建立数据库,采用频数分析法分析常见药物及证型,采用关联规则和复杂网络分析等数据挖掘方法分析组方规律.结果纳入处方202首,涉及证型18种,其中以气滞证比例最高,其次是阴虚证、湿热证、血虚证和肝胃不和证;涉及中药61味,用药频次前10位依次为当归、苦杏仁、柏子仁、火麻仁、半夏、陈皮、肉苁蓉、生地黄、白芍、大黄,药对有桔梗-苦杏仁,红花-桃仁,红花-当归等,角药有红花-郁李仁-桃仁,红花-郁李仁-当归,红花-当归-桃仁,白芍-大黄-厚朴等,并以相关药对为核心组成不同的核心处方.结论明清吴门医家多认为便秘为本虚标实,以辛润通络为其治疗大法,并重视活血化瘀、温阳及理气化痰等治法,强调便秘与肺、脾、肝和肾的关系.
Objective The characteristics of prescription medication for constipation in Wumen doctors in Ming and Qing Dynasties were analyzed by data mining method, so as to provide reference for the treatment of contemporary clinical constipation. Methods The Wumen medical school doctors in Ming and Qing Dynasties treating constipation in clinical case were selected for digital acquisition and process. The association rules and complex networks analysis were used for data mining in order to explore experience of famous doctors in Wumen medical treated constipation. Results A total of 202 cases records of constipation were collected from acient TCM books by the database of ancient books and literatures of library of Nanjing University of Traditional Chinese Medicine. The results showed that the highest syndromes of 202 prescriptions was Qi stagnation and yin deficiency, followed by damp-heat, blood deficiency and liver-stomach disharmony, and the top ten medicines for internal use were angelica, almond, arborvitae, flaxseed, pinellia, cistanche, dried rehamnnia root, radix paeoniae alba, rhubarb, poria, licorice, etc. The core medicine in pairs included the Platycodon grandiflorum-almonds, safflower-peach kernel, safflower-angelica and other drugs outside, carthami-semen pruni-Peach kernel, carthami-semen pruni-Angelica, carthami-angelica-peach, peony-rhubarb-magnolia. Conclusions Most of the doctors in the Ming and Qing Dynasties believed that constipation was based on deficiency and reality, took Xinrun Tongluo as its treatment method, and paid attention to the treatment of activating blood circulation, warming yang and regulating qi and resolving phlegm, and emphasized the relationship between constipation and lung, spleen, liver and kidney.
作者
王晓鹏
乐音子
孙明明
甄曙光
颜帅
Wang Xiaopeng;Yue Yinzi;Sun Mingming;Zhen Shuguang;Yan Shuai(Department of Colorectal Surgery,Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,China;Department of General Surgery,Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《国际中医中药杂志》
2019年第9期992-997,共6页
International Journal of Traditional Chinese Medicine
基金
中国博士后基金(2017M620220)
江苏省中医药管理局科技项目(YB2017061)
苏州市吴门医派研究专项科研基金(SYSD2017195)
苏州市科技发展计划项目(SYSD2015172)
苏州市中西医结合科研基金(SYSD2018212)
中华中医药学会青年人才托举工程项目(CACM-2018-QNRC2-C13)
苏州市第五批姑苏卫生人才培养项目(GSWS2019065)。
关键词
便秘(中医)
吴门医家
中医流派
数据挖掘
用药特色
配伍规律
中医药学文献
Constipation (TCM)
Wumen doctor
Traditional Chinese medicine schools
Data mining
Drug features
Regularity of comparability
Medicine pharmacologic literature (TCM)
作者简介
通信作者:颜帅,Email:plmokn74123@163.com,电话:0512-67872806。
