摘要
目的探讨患者数据移动均值法在新生儿遗传代谢病串联质谱检测中室内质量控制的应用方法和价值。方法收集新生儿筛查样本的串联质谱检测数据,采用常规商品化质控品联合患者数据移动均值法对串联质谱检测项目的室内质量控制进行监控,并评价其效果。结果根据患者数据移动均值法规则,发现20161027批次实验失败原因为分析前因素,即样本保存不当导致降解;20170620批次实验中使用的商品化质控品存在质量问题。结论患者数据移动均值法可有效帮助实验室管理室内质量控制,是串联质谱检测中无质控品指标的主要质控方法,是传统质控方法的有益补充。
Objective To explore the application method and value of patient data moving averaging method in internal quality control of neonatal genetic metabolic diseases screening by tandem mass spectrometry.Methods The neonatal genetic metabolic disease screening data were collected by tandem mass spectrometry.The internal quality control of tandem mass spectrometry testing items was monitored by using conventional commercial quality control products combined with patient data moving averaging method,and its effect was evaluated.Results According to the rule of the patient data moving averaging method,it was found the factors that caused the failure of 20161027 batches of experiments were the preanalysis factors,i.e.inappropriate sample preservation leading to degradation and the quality problems of the commercial quality control products used in the 20170620 batches of experiments.Conclusions The patient data moving averaging method can effectively help laboratory management of internal quality control.It is the main quality control method without quality control indicators in tandem mass spectrometry detection,and is a useful supplement to the traditional quality control methods.
作者
洪冬洋
王彦云
孙云
蒋涛
Hong Dongyang;Wang Yanyun;Sun Yun;Jiang Tao(Newborn Disease Screening Center,Women′s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Hospital),Nanjing 210004,China)
出处
《中华临床实验室管理电子杂志》
2019年第3期169-172,共4页
Chinese Journal of Clinical Laboratory Management(Electronic Edition）
关键词
移动均值法
串联质谱
室内质量控制
Moving averaging method
Tandem mass spectrometry(MS/MS)
Internal quality control
作者简介
通信作者:蒋涛,Email:jiangzhang784@163.com
