摘要
脓毒症急性肾损伤(acute kidney injury,AKI)时肾脏大循环和微循环呈现分离现象,肾脏血流正常甚至增加,而肾脏微循环缺血缺氧,表现为肾脏内血流分流,微循环灌注呈现异质现象,及微循环血流淤滞和梗阻,说明脓毒症AKI是一种微循环疾病,以微循环灌注为目标导向的治疗可能是今后的方向。
The renal hemodynamics in sepsis induced acute kidney injury(AKI)is characterized by renal macro-and microcirculation separation.In such case,renal blood flow is normal or even enhanced,while the renal microcirculation is in a state of ischemia and hypoxia because of the intrarenal blood shunt,heterogeneity,stasis and obstruction.This phenomenon suggests that septic AKI belongs to microcirculation disease,and“microcirculation perfusion guided”strategy should be a therapeutic goal in future.
作者
刘丽霞
王小亭
晁彦公
张宏民
武钧
尹万红
张丽娜
何伟
朱然
丁欣
张倩
胡振杰
无
Liu Lixia;Wang Xiaoting;Chao Yangong;Zhang Hongmin;Wu Jun;Yin Wanhong;Zhang Lina;He Wei;Zhu Ran;Ding Xin;Zhang Qian;Hu Zhenjie;无(Departmentof Critical Care Medicine,the Fourth Hospital of Hebei Medical,Shijiazhunag 050011,China;Departmentof Critical Care Medicine,Peking Union Medical College Hospital,Beijing 100730,China;Department of Critical Care Medicine,the First Hospital of Tsinghua University,Beijing 100010,China;Department of Critical Care Medicine,West China Hospital of Sichuan University,Chengdu 610041,China;Department of Intensive Care Unit,Xiangya Hospital Central South University,Changsha 410008,China;Department of Critical Care Medicine,Beijing Tongren Hospital,Beijing 100730,China;Department of Critical Care Medicine,Ruijin Hospital Afiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Critical Care Medicine,the First Hospital of China Medical University,Shenyang 110001,China;Chinese Critical Ultrasound Study Group)
出处
《临床荟萃》
CAS
2019年第7期595-598,共4页
Clinical Focus
关键词
脓毒症
急性肾损伤
sepsis
acute kidney injury
作者简介
通信作者:胡振杰,河北医科大学第四医院重症医学科主任,兼任急诊科主任,主任医师,教授,医学博士、硕士研究生导师。中国病理生理科学会危重病医学专业委员会副主任委员;中华医学会重症医学分会常务委员;中国医师协会重症医学医师分会常务委员;河北省医学会重症医学分会候任主任委员;河北省医师协会重症医学医师分会候任主任委员;河北省重症医学质量管理与控制中心主任;石家庄市医学会重症医学分会名誉主任委员,Email:syicu@vip.sina.com
