摘要
目的比较鼻咽癌调强放射治疗中自动计划(AP)与人工计划靶区和危及器官的剂量学差异。方法选取24例鼻咽癌调强放射治疗患者,在Pinnacle3 9.10计划系统上分别利用人工计划和AP方法设计调强放射治疗计划,根据两种不同计划的剂量体积直方图,评价靶区和脑干、脊髓等正常组织所受剂量的差异。结果AP和人工计划的靶区剂量分布均可以满足临床要求,靶区的D 2、D 98、V 107%、V 95%差异均无统计学意义(P>0.05),但是AP靶区的D 50和D mean大于人工计划,差异均有统计学意义(P<0.05)。人工计划中脊髓的D max,脑干的D max、Dmean,以及左右晶状体的D max均大于AP,差异均有统计学意义(P<0.05)。结论相对于人工计划,AP能节省时间,并且能在保证靶区剂量的前提下,更好地保护正常组织。
Objective The purpose of this study was to assess the feasibility of auto-planning (AP) technology in nasopharyngeal carcinoma by comparing the dosimetry differences between the auto-planning plan and the conventional manual plan. Methods 24 nasopharyngeal carcinoma patients were selected to perform the manual plan and the AP designing by use of the Pinnacle3 9.10 treatment planning system.The study examined the variation of dose-volume histogram between the manual plan and the AP.Two plans were compared among target dose distribution and the doses received by the organs at risk. Results Compared the manual plan with the AP,no statistical difference was found in D 2、D 98 、V 107% and V 95% ,but the D50 and Dmean of AP is larger than that of manual plan,and the difference is statistically significant( P <0.05). The maximum dose for spinal cord,the maximum dose and mean dose for brain stem,and the maximum dose for lens of the AP were considerably lower than the manual plan with statistical difference( P <0.05). Conclusion AP can achieve the requirement of clinical dose distribution as the manual plan.In addition,compared with manual planning,the AP groups could save more time and protect normal tissues better on the premise of target dose.
作者
周露
张书旭
彭莹莹
王琳婧
李慧君
Zhou Lu;Zhang Shuxu;Peng Yingying;Wang Linjing;Li Huijun(Radiation Therapy Center of Affiliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou Guangdong 510095,China)
出处
《医疗装备》
2019年第14期1-2,共2页
Medical Equipment
基金
广州市医药卫生科技项目(20181A011094)
关键词
鼻咽癌
调强放射治疗
自动计划
人工计划
Nasopharyngeal carcinoma
Intensity modulated radiotherapy
Auto planning
Manual planning
作者简介
通信作者:张书旭
