摘要
目的探讨血清人附睾上皮分泌蛋白4(HE4)和癌抗原125(CA125)单独和联合检测在卵巢上皮性肿瘤中的临床应用价值。方法将2013年1月至2015年3月南京医科大学附属南京妇幼保健院住院手术的32例卵巢上皮性恶性肿瘤和40例卵巢上皮性良性肿瘤患者纳入研究,比较血清HE4及CA125水平,并分析两者联合监测价值。结果卵巢良性病变组、Ⅰ-Ⅱ期卵巢癌组、Ⅲ-Ⅳ期卵巢癌组的HE4水平分别为(33.4±20.3)pmol/L、(128.3±33.1)pmol/L、(269.3±93.4)pmol/L,CA125水平(30.3±13.5)U/m L、(96.8±73.7)U/m L、(534.7±273.2)U/m L。Ⅰ-Ⅱ期卵巢癌组、Ⅲ-Ⅳ期卵巢癌组的HE4、CA125水平均显著高于卵巢良性肿瘤组,差异有统计学意义(t=11.55,P<0.001;t=5.51,P<0.001;t=15.42,P<0.001,t=11.73,P<0.001),Ⅲ-Ⅳ期卵巢癌患者HE4、CA125水平显著高于Ⅰ-Ⅱ期卵巢癌(t=4.68,P<0.001;t=4.95,P<0.001);两者联合检测敏感性及特异度均高于CA125(χ~2=12.13,P<0.001;χ~2=14.50,P<0.001),差异有统计学意义。结论 HE4和CA125联合检测有助于鉴别卵巢上皮性良性、恶性肿瘤,具有较高的灵敏度和特异度。
Objective To study the clinical application value of HE4 and CA125 in ovarian tumor.Methods 32 cases of ovarian cancer and 40 cases of benign ovarian tumor from January 2013 to March 2015 in Nanjing Maternity and Child Health Care Hospital were enrolled,and they were divided into ovarian cancer group and benign tumor group respectively,Then serum HE4 and CA125 levels content were compared,and the sensitivity,specificity value were analyzed.Results The serum HE4 levels of benign ovarian tumor,early-stage cancer group,advanced ovarian cancer group were( 33.4 ± 20.3),( 128.3 ± 33.1),( 269.3 ± 93.4) pmol / L respectively,and the serum CA125 levels were( 30.3 ± 13.5),( 96.8 ± 73.7),( 534.7 ± 273.2) U / m L,respectively.ovarian cancer group were higher than benign ovarian tumor( t = 11.55,P < 0.001;t = 5.51,P < 0.001;t = 15.42,P < 0.001,t = 11.73,P < 0.001),the serum HE4 and CA125 levels of advanced ovarian cancer group were higher than early-stage ovarian cancer,the differences were statiscally significant( t = 4.68,P < 0.001;t = 4.95,P < 0.001);HE4 combined with CA125 detection sentitivity,specificity were significantly higher than separate detection CA125( χ~2= 12.13,P < 0.001;χ~2= 14.50,P < 0.001).Conlusions HE4 and CA125 are usefull to identify property of ovarian tumor and diagnose ovarian cancer and benign ovarian tumor and have ideal sensitivity and specificity.
出处
《妇产与遗传（电子版）》
2015年第4期34-37,共4页
Obstetrics-Gynecology and Genetics (Electronic Edition)
