摘要
背景与目的肺癌是全球范围内发病率和死亡率最高的恶性肿瘤,导致其高病死率的主要原因是局部复发和远处转移,而转移部位对患者的预后有一定预测作用,本研究旨在比较不同远处转移部位的非小细胞肺癌(non-small cell lung cancer, NSCLC)患者的生存时间。方法从美国监测、流行病学和最终结果(Surveillance, Epidemiology, and End Result, SEER)数据库中提取出2010年-2014年间确诊的NSCLC患者共117,542例,回顾性分析其远处转移部位与生存时间的关系。结果在确诊的117,542例NSCLC患者中,42,071例(35.8%)患者病史中发生不同程度的远处转移,其中单器官转移26,932例,多器官转移15,139例,分别占转移患者总数的64.0%和36.0%。病史中无转移的患者的中位生存时间是21个月;而在病史中有转移患者中,中位生存时间分别是7个月(肺)、6个月(脑)、5个月(骨)、4个月(肝)、3个月(多器官转移),差异显著(P<0.001,肝转移与多器官转移除外P=0.650);且绝大多数NSCLC患者(88.4%)最终死于肺癌。结论 NSCLC患者远处转移提示预后差,在单器官转移患者中,肺转移预后最佳,肝转移预后最差;多器官转移患者预后差于单器官转移。
Background and objective The purpose of this study is to compare the survival time of non-small cell lung cancer(NSCLC)patients with different organ metastasis.Among all cancers,the morbidity and mortality of lung cancer is the highest worldwide,which may caused by local recurrence and distant metastasis,and the location of metastasis may predict the prognosis of patients.Methods A total of 117,542 patients with NSCLC diagnosed between 2010 and 2014 were enrolled from Surveillance,Epidemiology,and End Result(SEER)databases,and the relationship between distant metastasis and survival time was retrospectively analyzed.Results Of all the 117,542 patients diagnosed with non-small cell lung cancer,42,071(35.8%)patients had different degrees of distant metastasis during their medical history,including 26,932 single organ metastases and 15,139 multiple organ metastases,accounting for 64.0%and 36.0%of the metastatic patients respectively.Compared with patients with no metastasis,whose median survival time was 21 months,the median survival time of patients with metastases was 7 months(lung),6 months(brain),5 months(bone),4 months(liver),and 3 months(multiple organ)respectively,and the difference was significant(P<0.001,except liver vs multiple organ P=0.650);Most patients with NSCLC(88.4%)eventually died of lung cancer.Conclusion Distant metastasis of NSCLC patients indicates poor prognosis.In NSCLC patients with single organ metastasis,the prognosis of lung metastasis is the best,and liver metastasis is the worst,and multiple organ metastasis is worse than single organ metastasis.
作者
吴炳群
魏慎海
田进涛
宋小平
胡鹏程
崔永
Bingqun WU;Shenhai WEI;Jintao TIAN;Xiaoping SONG;Pengcheng HU;Yong CUI(Department of Thoracic Surgery,First Affiliated Hospital of Tsinghua University,Beijing 100016,China;Department of Thoracic Surgery,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China)
出处
《中国肺癌杂志》
CAS
CSCD
北大核心
2019年第2期105-110,共6页
Chinese Journal of Lung Cancer
关键词
肺肿瘤
转移
中位生存时间
Lung neoplasms
Metastasis
Median survival time
作者简介
通讯作者:崔永,E-mail:cywork1@sina.com.
