摘要
目的评价利水类中药联合腹腔灌注化疗对卵巢癌腹腔积液的客观疗效和安全性。方法检索CochraneLibrary、EMbase、CBM、PubMed、VIP和WanFangData数据库1998年1月25日至2017年12月25日的利水类中药联合腹腔灌注化疗治疗卵巢癌腹腔积液的临床对照研究。参考Cochrane系统评价手册的质量评价标准对纳入文献进行质量评价后,使用RevMan5.2软件进行Meta分析。结果共11篇文献包含778例患者符合纳入标准。Meta分析表明,利水类中药联合腹腔灌注化疗治疗卵巢癌腹腔积液的客观疗效优于对照组,其差异有统计学意义(OR为0.26,95%CI0.18,0.37)。结论利水类中药联合腹腔灌注化疗对卵巢癌腹腔积液的疗效较好,推荐结合患者具体情况进行临床应用。
Objective To assess objective efficacy and safety of Chinese materia medica for promoting urination combined with intraperitoneal perfusion chemotherapy in the treatment of ovarian cancer ascites. Methods Controlled clinical trails on Chinese materia medica for promoting urination combined with intraperitoneal perfusion chemotherapy in treating ovarian cancer ascites were retrieved from Cochrane Library, EMbase, CBM, PubMed, VIP and Wanfang Data from January 25, 1998 to December 25, 2017. According to quality assessment criteria in Cochrane manual of system assessment, included literatures were performed quality assessment. And meta-analysis was performed by RevMan 5.2 software. Results A total of 11 literatures involving 778 patients met the inclusion criteria. Meta-analysis indicated that the objective efficacy of Chinese materia medica for promoting urination combined with intraperitoneal perfusion chemotherapy was better than that in the control group in the treatment of ovarian cancer ascites, with statistically significant difference (OR=0.26, 95% CI [0.18, 0.37]). Conclusion Chinese materia medica for promoting urination combined with intraperitoneal perfusion chemotherapy has good efficacy in the treatment of ovarian cancer ascites, which is recommended for clinical application while combining specific situation of the patient.
作者
刘畅
刘梦琳
孙晓峰
LIU Chang;LIU Menglin;SUN Xiaofeng(Hunan University of Chinese Medicine, Changsha, Hunan 410208, China)
出处
《湖南中医药大学学报》
CAS
2019年第10期1222-1226,共5页
Journal of Hunan University of Chinese Medicine
基金
国家自然科学基金项目(81774362)
湖南中医药大学“十三五”一级学科基础医学建设项目(2018JCYX06)
关键词
利水类中药
卵巢癌
腹腔积液
META分析
随机临床试验
Chinese materia medica for promoting urination
ovarian cancer
ascites
Meta-analysis
randomized clinical trial
作者简介
刘畅,女,硕士,研究方向:肿瘤的中西医防治;通讯作者:孙晓峰,女,副教授,博士,E-mail:2642724115@qq.com.
