摘要
目的研究维持性血液透析患者高频透析相关低血压(intradialytic hypotension,IDH)与透析后乳酸水平之间的关系。方法选取2018年1~12月间在首都医科大学附属北京朝阳医院血液净化科115例规律维持性血液透析患者为研究对象,根据是否发生高频IDH(3个月透析中IDH发生频率≥30%)分为观察组和对照组。记录患者的一般资料和实验室资料,采取独立样本t检验探讨观察组与对照组患者透析前透析后血气分析和透析前血常规、肾功能、离子、尿酸、血糖、C反应蛋白等之间的关系。采用二元Logistic回归分析高频IDH的重要影响因素。绘制受试者工作特征曲线,评价透析后乳酸对高频IDH的诊断价值。P<0.05为差异具有统计学意义。结果高频IDH的患者占23.48%(27/115)。观察组患者红细胞平均血红蛋白浓度较对照组低[(321.670±10.144)g/L比(328.659±10.974)g/L, t=-2.944,P=0.004],红细胞分布宽度-CV升高(14.496%±1.535%比13.686%±0.945%,t=2.594,0.014),透析后血气分析乳酸升高[(1.881±0.627)mmol/L比(1.437±0.700)mmol/L,t=2.949, P=0.004],差异具有统计学意义。Logistic回归分析显示红细胞分布宽度-CV升高和透析后乳酸升高是透析高频IHD发生的危险因素(OR=1.630,95%CI 1.046~2.539,P=0.031;OR=2.364,95%CI1.237~4.517,P=0.009)。ROC曲线显示,透析后乳酸曲线下面积AUC=0.721,95%CI 0.605~0.837, P=0.001。结论透析后乳酸升高是高频IDH的危险因素,具有一定的预测价值。
Objective To study the relationship between high frequency dialysis related intradialytic hypotension(IDH) and post-dialysis lactic acid level in maintenance hemodialysis(MHD) patients. Methods A total of 115 patients with regular MHD were enrolled in this study. These patients were treated in the Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University during the period from January 1 st, 2018 to January 1 st, 2019. According to the prevalence of high frequency dialysis related IDH in the 3 months of dialysis period, they were divided into observation group(the prevalence ≥30%) and control group(the prevalence <30%). Their clinical and laboratory data were recorded. Independent sample t test was used to investigate the relationships between the blood gas changes before and after dialysis and the pre-dialytic blood routine, renal function, ions, uric acid, blood sugar and C-reactive protein in observation group and control group. Binary logistic regression was used to analyze the important factors influencing the high frequency dialysis related IDH. Receiver operating characteristic(ROC) curve was used to evaluate the value of lactic acid for the diagnosis of high frequency dialysis related IDH. P<0.05 was considered to be statistically significant. Results Patients with high-frequency dialysis related IDH accounted for 23.48%(27/115) of the patients. Compared with those in control group, mean hemoglobin concentration of red blood cells was lower(321.670±10.144 g/L vs. 328.659±10.974 g/L, t=-2.944, P=0.004), red blood cell distribution width(RDW-CV) was higher(14.496±1.535% vs. 13.686±0.945%, t=2.594, P=0.014), and post-dialysis lactic acid was higher(1.881±0.627 mmol/L vs. 1.437±0.7 mmol/L, t=2.949, P=0.004) in observation group. Binary logistic regression showed that the higher levels of red blood cell distribution width and post-dialysis lactic acid were the risk factors for high-frequency dialysis related IDH(OR=1.630, 95% CI 1.046~2.539, P=0.031;OR=2.364, 95% CI 1.237~4.517, P=0.009). ROC curve demonstrated that the area under the curve(AUC) of lactic acid was 0.721(95% CI 0.605~0.837, P=0.001). Conclusions The increase of post-dialysis lactic acid is an important risk factor for high frequency dialysis related IDH and is valuable for the prediction of the IDH.
作者
祖源
喻倩
李寒
王世相
ZU Yuan;YU Qian;LI Han;WANG Shi-xiang(Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China)
出处
《中国血液净化》
CSCD
2019年第10期669-672,共4页
Chinese Journal of Blood Purification
关键词
肾透析
低血压
乳酸
Renal dialysis
Hypotension
Lactic acid
作者简介
通讯作者:李寒,100020北京,首都医科大学附属北京朝阳医院血液净化科,Email:hanli@ccmu.edu.cn.
