摘要
目的探讨糖皮质激素(GCs)联合阿奇霉素治疗小儿大叶性肺炎的效果以及对血清炎性因子水平的影响。方法将118例大叶性肺炎患儿随机分为对照组与观察组,每组59例。对照组予以阿奇霉素治疗,观察组采用甲泼尼龙联合阿奇霉素治疗。比较2组的治疗效果、症状、体征以及血清C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、降钙素原(PCT)等炎性因子水平的变化。结果观察组热退时间、咳喘和啰音消失时间、肺部阴影吸收时间、住院时间以及治疗后血清CRP、TNF-α、IL-6、PCT水平均显著优于对照组(P<0.05),治疗总有效率显著高于对照组(P<0.05)。结论GCs联合阿奇霉素治疗小儿大叶性肺炎疗效确切,可迅速缓解临床症状及体征,缩短病程,且安全性良好。
Objective To investigate the efficiency of glucocorticoids (GCs) combined with azithromycin in treatment of children with lobar pneumonia and its influence on levels of serum inflammatory factors.Methods Totally 118 children with lobar pneumonia were randomly divided into control group and observation group,with 59 cases in each group.The control group was treated with azithromycin,and the observation group was treated with methylprednisolone plus azithromycin.The therapeutic effect,symptoms,signs and changes of serum C-reactive protein (CRP),tumor necrosis factor-α(TNF-α),interleukin-6 (IL-6),procalcitonin (PCT) and other inflammatory factors were compared between the two groups.Results The fever regression time,cough and rale disappearance time,lung shadow absorption time,hospitalization time,and levels of serum CRP,TNF-α,IL-6 and PCT in the observation group were significantly better than those in the control group ( P <0.05),and the total effective rate was significantly higher than that in the control group ( P <0.05).Conclusion GCs combined with azithromycin is effective in the treatment of children with lobar pneumonia,which can quickly alleviate clinical symptoms and signs,shorten the course of disease,and the safety isgood.
作者
邓群花
王润青
DENG Qunhua;WANG Runqing(Zhouzhi County People′s Hospital,Xi′an,Shaanxi,710499;Hancheng People′s Hospital,Weinan,Shaanxi,715401)
出处
《实用临床医药杂志》
CAS
2019年第17期75-78,共4页
Journal of Clinical Medicine in Practice
关键词
大叶性肺炎
糖皮质激素
阿奇霉素
疗效
炎性因子
lobar pneumonia
glucocorticosteroids
azithromycin
efficiency
inflammatory factors
作者简介
通信作者:王润青,E-mail:1064421875@163.com.
