摘要
目的探讨影响Ⅰ~Ⅱ期子宫内膜癌复发的相关危险因素。方法回顾性分析南京鼓楼医院2010年1月—2017年12月间收治的516例Ⅰ~Ⅱ期子宫内膜癌患者,随访患者的复发情况。结果516例Ⅰ~Ⅱ期子宫内膜癌患者中,46例复发,复发率为8.91%。年龄、体重、血压、手术病理分期、病理类型、ER及PR低表达与Ⅰ~Ⅱ期子宫内膜癌复发存在相关性(P<0.05)。糖尿病、脉管转移、病理分化程度、淋巴结切除、腹水细胞学检查与Ⅰ~Ⅱ期子宫内膜癌复发不存在相关性(均P>0.05)。年龄、体重、血压是Ⅰ~Ⅱ期子宫内膜癌复发的独立危险因素(均P<0.05)。结论年龄、体重、血压、手术病理分期、病理类型、ER及PR表达影响Ⅰ~Ⅱ期子宫内膜癌复发,高龄、低体重、高血压是影响Ⅰ~Ⅱ期子宫内膜癌复发的独立危险因素。在临床工作中,需要对Ⅰ~Ⅱ期高龄、低体重、高血压高危因素的子宫内膜癌患者密切随访,早期发现复发病灶并及时治疗。
Objective To investigate the risk factors of the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma. Methods We retrospectively analyzed the data of 516 patients with stage Ⅰ-Ⅱ endometrial carcinoma treated in Nanjing Drum Tower Hospital from January 2010 to December 2017. The recurrence rate of the patients was followed up. Results The recurrence rate was 8.91%(46/516). Age, body weight, hypertension, stage of operation and pathology, pathological type, low expression of ER and PR were correlated with the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma (P<0.05). Diabetes mellitus, vascular metastasis, pathological differentiation, lymph node excision and ascites cytologic examination were not correlated with the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma (P>0.05). Age, body weight and blood pressure were independent risk factors for the recurrence of stageⅠ-Ⅱendometrial carcinoma (P<0.05). Conclusion Age, body weight, hypertension, stage of operation and pathology, pathological type, low expression of ER and PR affect the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma. Advanced age, low body weight and hypertension are independent risk factors for the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma. In clinical work, we should follow up closely stage Ⅰ-Ⅱ endometrial carcinoma patients with advanced age, low body weight and hypertension, for early detection and in-time treatment of recurrence lesions.
作者
张正宇
凌静娴
李荣
韩克
朱湘虹
汤晓秋
周怀君
ZHANG Zhengyu;LING Jingxian;LI Rong;HAN Ke;ZHU Xianghong;TANG Xiaoqiu;ZHOU Huaijun(Department of Gynecology,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210000,China;Department of Gynecology,Hongze District People’s Hospital,Huai’an City,Huai’an 223100,China)
出处
《肿瘤防治研究》
CAS
CSCD
2019年第9期807-810,共4页
Cancer Research on Prevention and Treatment
基金
江苏省自然科学基金(BK20151096)
南京市卫计委重点课题(ZKX17015)
关键词
子宫内膜癌
复发
多因素分析
Endometrial carcinoma
Recurrence
Multivariate analysis
作者简介
张正宇(1977-),男,本科,副主任医师,主要从事妇科肿瘤的研究;通信作者:周怀君,E-mail:zhouhj2007@126.com.
