摘要
目的探讨通络解毒化浊汤对慢性萎缩性胃炎(chronic atrophic gastritis, CAG)患者血液流变学及胃液成分的影响。方法将符合入选标准的84例CAG患者按随机数字表法分为2组,每组42例。对照组采用西医常规疗法治疗,观察组在对照组基础上加服通络解毒化浊汤。2组均连续治疗4周。分别于治疗前后进行临床症状评分,采用全自动血液流变仪检测全血黏度、血浆黏度、红细胞压积、纤维蛋白原及红细胞聚集指数;采集胃液,以pH计检测胃酸pH值,采用酸碱中和滴定法检测胃游离酸,比色法检测胃蛋白酶水平,紫外分光光度法检测亚硝酸盐水平,评价临床疗效。结果观察组总有效率为90.5%(38/42)、对照组为76.2%(32/42),2组比较差异有统计学意义(Z=-2.683,P<0.05)。治疗后,观察组胃脘疼痛、胃部胀满、恶心呕吐、反酸、食少纳呆评分均低于对照组(t值分别为4.865、4.632、4.716、4.582、4.433,P值均<0.05);全血黏度、血浆黏度、红细胞压积、纤维蛋白原及红细胞聚集指数均低于对照组(t值分别为5.044、4.462、5.274、4.231、4.485,P值均<0.05);胃液pH值[(2.28±0.33)比(2.75±0.38),t=4.825]和亚硝酸盐[(33.27±4.45)mg/L比(38.80±4.93)mg/L,t=5.136]水平均低于对照组(P<0.05),游离酸[(22.13±3.36)mmol/L比(18.65±2.54)mmol/L,t=5.382]和胃蛋白酶[(144.56±15.86)U比(137.16±14.63)U,t=5.736]水平均高于对照组(P<0.05)。结论通络解毒化浊汤可改善CAG患者血液流变学指标,调节胃液分泌,有助于保护胃黏膜,提高临床疗效。
Objective To observe the effects of Tongluo-Jiedu-Huazhuo decoction on hemorheological indexes and gastric juice components in patients with chronic atrophic gastritis. Methods According to the inclusion criteria, 84 patients with chronic atrophic gastritis were randomly divided into the observation group and the control group, with 42 cases in each group. The control group received the routine clinical treatment, and the observation group was treated with Tongluo-Jiedu-Huazhuo decoction on the basis of the control group. The clinical symptoms were scored before and after treatment. The blood viscosity, plasma viscosity, hematocrit, fibrinogen and erythrocyte aggregation index were measured by automatic hemorheology instrument, and gastric juice pH, free acid, pepsin and nitrite levels were measured by serial gastric juice detection method. The clinical efficacy was evaluted. Results The total effective rate of the observation group was 90.5%(38/42), and the total effective rate of the control group was 76.2%(32/42), with statistically significant difference (Z=-2.683, P<0.05). After treatment, the scores of epigastric pain, stomach swelling, nausea and vomiting, acid reflux and dietary deficiency in the observation group were significantly lower than those in the control group (t were 4.865, 4.632, 4.716, 4.582, 4.433, respectively, all Ps<0.05), and the whole blood viscosity, plasma viscosity, hematocrit, fibrinogen and erythrocyte aggregation index were significantly lower than those in the control group (t were 5.044, 4.462, 5.274, 4.231 and 4.485, respectively, all Ps<0.05). The gastric juice pH (2.28 ± 0.33 vs. 2.75 ± 0.38, t=4.825), nitrite (33.27 ± 4.45 mg/L vs. 38.80 ± 4.93 mg/L, t=5.136) in the observation group were significantly lower than the control group (P<0.05). The free acid (22.13 ± 3.36 mmol/L vs. 18.65 ± 2.54 mmol/L, t=5.382), pepsin (144.56 ± 15.86 U vs. 137.16 ± 14.63 U, t=5.736) in the observation group were significantly higher than the control group (P<0.05). Conclusions The application of Tongluo-Jiedu-Huazhuo decoction in patients with chronic atrophic gastritis can improve the hemorrheology index and regulate the function of gastric secretion, which is helpful to protect the gastric mucosa and relieve the clinical symptoms.
作者
邢建伟
史凤磊
苏秋菊
Xing Jianwei;Shi Fenglei;Su Qiuju(Department of Traditional Chinese Medicine, Qingdao Municipal Hospital, Qingdao 266000, China)
出处
《国际中医中药杂志》
2019年第8期805-808,共4页
International Journal of Traditional Chinese Medicine
关键词
胃炎
萎缩性
通络解毒化浊汤
胃液成分
血液流变学
胃分泌功能
Gastritis
atrophic
Tongluo-Jiedu-Huazhuo decoction
Gastric juice components
Hemorrheology
Gastric secretory function
作者简介
通信作者:苏秋菊,Email:sqj6721@163.com,电话:1866166821.
