摘要
目的:探讨乌司他丁联合生长抑素治疗上消化道出血的疗效及对患者的影响。方法:选取本院收治的上消化道出血患者84例,按随机数字表法分为研究组和对照组,每组42例。对照组采用生长抑素治疗,研究组采用乌司他丁联合生长抑素治疗。比较两组患者的治疗效果,炎性因子变化,出血停止时间、住院时间及不良反应情况。结果:研究组临床总有效率为85.70%,高于对照组的57.10%;研究组血清肿瘤坏死因子α、白细胞介素(IL)-6水平均低于对照组,但IL-10、IL-2水平均高于对照组;研究组出血停止时间及住院时间均短于对照组;两组比较差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:乌司他丁联合生长抑素治疗上消化道出血能够提高临床治疗效果,改善患者血清炎性因子水平,利于缩短患者的出血时间,促进患者恢复。
Objective:To investigate effects of Ulinastatin combined with somatostatin on upper gastrointestinal bleeding and its influence on the patients.Methods:Eighty-four patients with upper gastrointestinal bleeding admitted to our hospital were enrolled in this study.These patients were divided into study group and control group according to the random number table method,42 cases in each group.The control group was treated with somatostatin,while the study group was treated with Ulinastatin combined with somatostatin.The treatment effectS,inflammatory factor changes,bleeding stop time,hospital stay and adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 85.70%,which was significantly higher than that of the control group of 57.10%.The serum levels of TNF-αand interleutin-6(IL-6)in the study group were significantly lower than those in the control group,and the levels of IL-10 and IL-2 were significantly higher than those in the control group.The bleeding stop time and hospital stay of the study group were significantly shorter than the control group;and the differences between the two group were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ulinastatin combined with somatostatin in the treatment of upper gastrointestinal bleeding can improve the clinical treatment effects,improve the serum inflammatory factor levels in the patients,and help to shorten the bleeding time and promote the recovery.
作者
李兆雷
LI Zhaolei(Jiamusi Maternal and Child Health Hospital,Jiamusi 154002 Heilongjiang,China)
出处
《中国民康医学》
2019年第13期23-25,共3页
Medical Journal of Chinese People’s Health
关键词
生长抑素
乌司他丁
上消化道出血
炎性因子
Somatostatin
Ulinastatin
Upper gastrointestinal bleeding
Inflammatory factor
