川芎嗪联合乌司他丁治疗重症急性胰腺炎并发脓毒血症的疗效观察被引量：9

Efficacy of ligustrazine combined with ulinastatin for treating severe acute pancreatitis complicated with sepsis

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摘要目的探讨川芎嗪联合乌司他丁治疗重症急性胰腺炎(SAP)并发脓毒血症患者的临床疗效。方法选取SAP并发脓毒血症患者65例,随机分为观察组33例和对照组32例。两组均给予乌司他丁治疗,在此基础上观察组加用川芎嗪治疗。比较两组患者治疗后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)水平、C-反应蛋白(CRP)水平、D-二聚体水平、白细胞计数、B细胞比例、T细胞比例、自然杀伤细胞比例、急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)评分及治疗效果。结果治疗后,观察组患者疗效优于对照组,手术率低于对照组(均P<0.05);两组患者血清CRP、PT、APTT、FIB和D-二聚体水平、白细胞计数及APACHEⅡ评分均低于治疗前,且观察组低于对照组(均P<0.05)。结论川芎嗪联合乌司他丁治疗SAP并发脓毒血症患者可以降低炎症因子水平,改善凝血功能,有效缓解临床症状,提高疗效,降低手术率。 Objective To explore the clinical efficacy of ligustrazine combined with ulinastatin for treating patients with severe acute pancreatitis(SAP) complicated with sepsis. Methods Sixty-five SAP patients complicated with sepsis were randomly divided into observation group(33 cases) and control group(32 cases).Both groups were treated with ulinastatin,based on which the observation group received ligustrazine additionally.After treatment, the two groups were compared in terms of prothrombin time(PT),activated partial prothrombin time(APTT),fibrinogen(FIB)level,C-reactive protein(CRP)level,D-dimer level,WBC count,ratio of B cells,ratio of T cells,ratio of natural killer cells,the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHEⅡ)score,and therapeutic effects. Results After treatment,the observation group had a better efficacy and a lower rate of surgery than the control group(all P <0.05);serum CRP,PT,APTT,FIB and D-dimer levels,WBC count,and APACHEⅡ score were lower in both groups compared with those before treatment,and the indices mentioned above in the observation group were lower than those in the control group(all P <0.05). Conclusion Ligustrazine combined with ulinastatin can reduce inflammatory factors levels ,improve coagulation function,achieve effective clinical symptoms remission,improve efficacy,and reduce rate of surgery in the treatment of SAP patients complicated with sepsis.

作者高健敏朱勇德胡清甫 GAO Jian-min;ZHU Yong-de;HU Qing-fu(Department of Emergency,the Third People′s Hospital of Hainan Province,Sanya 572000,China;Department of Emergency,the People′s Hospital of Sanya City,Sanya 572000,China)

机构地区海南省第三人民医院急诊科海南省三亚市人民医院急诊科

出处《广西医学》 CAS 2019年第13期1649-1653,共5页 Guangxi Medical Journal

关键词重症急性胰腺炎脓毒血症临床疗效川芎嗪乌司他丁凝血功能炎症因子 Severe acute pancreatitis Sepsis Clinical efficacy Ligustrazine Ulinastatin Coagulation function Inflammatory factor

分类号 R576.1 [医药卫生—消化系统]

作者简介高健敏(1986~),女,本科,主治医师,研究方向:急诊疾病临床诊疗,电子邮箱:gaojianminjzk@163.com.