摘要
目的 评估降钙素原(PCT)和尿酸在预测脓毒症患者预后中的价值.方法 回顾性分析了215例脓毒症患者,根据患者发病后28天的生存情况,分为存活组(159例)和死亡组(56例).入院后获取一般资料,进行急性生理学与慢性健康状况评分系统Ⅱ(APACHE-Ⅱ)评分,检测PCT、尿酸、肌钙蛋白Ⅰ等指标.结果 存活组与死亡组的年龄、APACHE-Ⅱ评分、平均血小板体积(MPV)、C反应蛋白(CRP)、D二聚体5个指标间比较,差异有统计学意义(P均<0.05);死亡组的PCT水平明显高于存活组(P<0.05),死亡组的尿酸水平也明显高于存活组(P<0.05).Logistic回归分析提示PCT和尿酸均是脓毒症患者预后的相关因素(P<0.05).结论 PCT和尿酸是脓毒症预后判断的重要生物学标志物.
Objective To evaluate the value of PCT and uric acid in predicting the prognosis of patients with sepsis.Methods Totally 215 patients with sepsis were chosen to participate this retrospective study.According to whether the patient survives or not in 28 days after the onset of illness,they were divided into survival group (159 cases) and death group (56 cases).Basic information of the patients were gotten,the Acute Physiology and Chronic Health Status Scoring System Ⅱ(APACHE-Ⅱ) score was performed,as well as indicators such as PCT,uric acid,and troponin I,etc.were tested.Results There were significant differences in age,APACHE-Ⅱ score,MPV,CRP,and D-dimer between the survival group and the death group (all P <0.05).The PCT level of the death group was significantly higher than that of the survival group ( P <0.05).The uric acid level in the death group was also significantly higher than that in the survival group ( P <0.05).Logistic regression showed that PCT and uric acid were relevant factors for prognosis in patients with sepsis ( P <0.05).Conclusion PCT and uric acid can be used as important biological indicators to judge the prognosis of sepsis.
作者
杨素素
李钰
徐建国
潘景业
Yang Susu;Li Yu;Xu Jianguo(Wenzhou Third Clinical Insitute of Wenzhou Medical University,Zhejiang 325000,China)
出处
《医学研究杂志》
2019年第7期113-116,共4页
Journal of Medical Research
基金
浙江省温州市公益性科技计划项目(Y20170744)
关键词
脓毒症
降钙素原
尿酸
Sepsis
Procalcitonin
Uric acid
作者简介
通讯作者:潘景业,电子信箱:13575414224@163.com.
