摘要
目的:基于文献荟萃分析(Meta分析)方法,系统评价甲钴胺治疗前庭神经炎的有效性,以期更有效地指导临床用药.方法:检索中国知网、万方数据库、维普数据库及PubMed等数据库,纳入甲钴胺治疗前庭神经炎的随机对照试验(观察组干预措施为使用甲钴胺,对照组为不含有甲钴胺,两组患者可同时使用其他药物和前庭康复训练等治疗).按照Jadad质量计分法对纳入文献进行方法学质量评估,采用RevMan 5.3.0进行Meta分析.结果:共纳入6篇文献,涉及505例患者,其中观察组患者259例,对照组患者246例.Meta分析结果显示,治疗后6个月,两组患者冷热水/气试验半规管轻瘫程度改善情况的差异有统计学意义(MD=-3.67,95%CI=-5.81^-1.54,P<0.01).治疗后3个月,两组患者眩晕残障程度评定量表(dizziness handicap inventory,DHI)评分的差异有统计学意义(MD=-7.00,95%CI=-10.07^-3.92,P<0.01);治疗后1个月、6个月,两组患者DHI评分的差异无统计学意义(P>0.05).甲钴胺无明显不良反应报道,安全性高.结论:甲钴胺治疗前庭神经炎,能有效促进前庭外周神经的恢复,快速减轻临床症状,且安全性高.
OBJECTIVE:To systematically review the efficacy of mecobalamin in treatment of vestibular neuritis based on Meta-analysis,so as to provide more effective guidance for clinical medication.METHODS:Randomized controlled trials of mecobalamin in treatment of vestibular neuritis(the observation group was given mecobalamin for intervention while the control group was not,both groups could be treated with other drugs and vestibular rehabilitation training)were retrieved from databases of CNKI,Wanfang,VIP,PubMed.Methodological quality assessment on involved literature was processed by Jadad quality scoring method,and RevMan 5.3.0 was adopted to conduct Meta analysis.RESULTS:A total of 6 studies were involved,including 505 patients,of which 259 cases were observation group and 246 cases were control group.Results of Meta analysis indicated that after 6-month treatment,there was a statistically significant difference in the improvement of canal paresis in cold hot water/gas test of the two groups(MD=-3.67,95%CI=-5.81--1.54,P<0.01).After 3-month treatment,the difference in scores of dizziness handicap inventory(DHI)between two groups was statistically significant(MD=-7.00,95%CI=-10.07--3.92,P<0.01);at 1 month and 6 months after treatment,there were no statistical significance in differences in DHI scores between two groups(P>0.05).There had no adverse drug reaction reported.CONCLUSIONS:Mecobalamin in treatment of vestibular neuritis can effectively promote the recovery of vestibular peripheral nerves,rapidly reduce clinical symptoms,with good safety.
作者
李莎恩
张永昕
段付军
张丹
LI Sha’en;ZHANG Yongxin;DUAN Fujun;ZHANG Dan(Dept.of Preventive Health Care,Air Force Hospital of Southern Theater Command PLA,Guangdong Guangzhou 510602,China;Dept.of Pharmacy,Air Force Hospital of Southern Theater Command PLA,Guangdong Guangzhou 510602,China;Dept.of Avation Disease,Air Force Hospital of Southern Theater Command PLA,Guangdong Guangzhou 510602,China)
出处
《中国医院用药评价与分析》
2019年第7期856-859,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
甲钴胺
前庭神经炎
META分析
Methylcobalamin
Vestibular neuritis
Meta-analysis
作者简介
李莎恩,主治医师。研究方向:疾病健康管理。E-mail:14774630@qq.com;通信作者:张永昕,主管药师。研究方向:医院药学。E-mail:20691072@qq.com.
