摘要
目的探讨间苯三酚联合地屈孕酮治疗先兆流产的疗效及对患者血清孕酮水平和血红素氧合酶-1的影响。方法选取2017年10月-2018年10月来院治疗的86例先兆流产孕妇作为研究对象,按随机数字表法等分为试验组和对照组,各43例,对照组给予间苯三酚注射剂治疗,试验组在此基础上给予地屈孕酮片治疗,用药2周后,比较两组孕妇血清孕酮(Progesterone,P)、血红素氧合酶-1(Heme oxygenase-1,HO-1)水平以及有效率。结果用药前,两组患者的P和HO-1水平无明显差异(P> 0. 05);用药后均升高,但试验组的变化幅度更明显,两者存在显著性差异(P <0. 05);且试验组P水平用药前后存在更为显著的差异(P <0. 01);用药后,对照组的有效率为72. 09%(31/43),远低于试验组的90. 70%(39/43),两者比较有显著性差异(P <0. 05)。结论间苯三酚联合地屈孕酮治疗先兆流产,不仅疗效确切,而且能够有效提高自身黄体酮和血红素氧合酶-1水平,降低先兆流产风险,改善分娩,值得进一步应用于临床。
Objective To investigate the efficacy of phloroglucinol combined with didrogesterone in the treatment of threatened abortion and its effect on serum progesterone level and heme oxygenase-1 in patients with threatened abortion.Methods 86 patients with high-risk HPV infection of cervix treated in our hospital from October 2017 to October 2018 were selected as the research objects. They were divided into experimental group and control group according to random number table method,43 cases in each group. The control group was treated with phloroglucinol injection. The experimental group was treated with didrogesterone tablets on this basis. After 2 weeks of treatment,the Levels of heme oxygenase-1( HO-1) and effective rate and the serum progesterone of pregnant women in the two groups was compared. Results There was no significant difference in P and HO-1 levels between the two groups before and after treatment( P > 0. 05),but the changes were more obvious in the experimental group( P < 0. 05),and there was a more significant difference in P level between the experimental group and the control group( P < 0. 01);after treatment,the effective rate of the control group was72. 09%( 31/43),which was much lower than that of the control group 90. 70%( 39/43). There was a significant difference between the two groups( P < 0. 05). Conclusion Phloroglucinol combined with didrogesterone in the treatment of threatened abortion is not only effective,but also can effectively improve the level of progesterone and heme oxygenase-1,reduce the risk of threatened abortion and improve delivery. It is worth further clinical application.
作者
马玲
祝费隐
MA Ling;ZHU Feiyin(First Affiliated Hospittil of Jiangxi Medical College, Shangrao 334000, China)
出处
《现代医院》
2019年第6期881-883,共3页
Modern Hospitals
基金
上饶市科技计划项目(20161CZD05)
关键词
先兆流产
地屈孕酮
间苯三酚
血清孕酮
血红素氧合酶-1
临床疗效
Threatened Abortion
Didrogesterone
Phloroglucinol
Serum Progesterone
Heme Oxygenase-1
Clinical Efficacy
