摘要
目的为临床制定中国健康成年男性血清糖类抗原19-9(CA19-9)参考值统一标准提供科学依据。方法建立9382例分布于全国64个市县的健康成年男性血清CA19-9参考值数据库,结合主成分分析、变异系数、相关分析进行地理指标体系降维并建立分类回归树模型;依据2322个观测数据点绘制血清CA19-9参考值冷热点联合空间分布图。结果血清CA19-9参考值空间分布总体表现为南高北低,东北地区的吉林、辽宁等地高于中东部地区。热点多分布于南部地区,冷点多分布于北部地区。结论健康成年男性CA19-9参考值空间分布存在差异性,临床诊断需考虑地域性差异。
Objective To provide clinical criteria with regional basis of the reference values of carbohydrateantigen 19-9 (CA19-9) in healthy Chinese male adults. Methods First,the reference values of CA19-9 in 9,382 healthy male adults distributed in 64 cities and counties in China were collected to construct the database. Then geographical factors received dimensionality reduction by comprehensive application of the principal component analysis,variation coefficient method,and correlation analysis;then the classification regression tree model was constructed. Third,the hotspot and spatial distribution of the reference values of CA19-9 in healthy male adults was drawn based on 2,322 observation data points. Results The reference value of CA19-9 showed spatial variation,which was higher in the southern region than in the northern region,and higher in Jilin and Liaoning provinces than in the eastern central region. Hotspots were mostly distributed in the southern region,and cold spots in the northern region. Conclusion There exist spatial variation of the reference values of CA19-9 at spatial level. Therefore,when it comes to clinical diagnosis,it is necessary to consider regional variation.
作者
杨绍芳
葛淼
潘池钦
李小平
薛然尹
YANG Shao-fang;GE Miao;PAN Chi-qin;LI Xiao-ping;XUE Ran-yin(Institute of Health Geography,Xi'an 710119;Forest Inventory and Planning Institute of Guizhou,Guiyang 550000;Tianjin Smart CityResearch Institute,Tianjin 300300,China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2019年第4期635-639,共5页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
国家自然科学基金资助项目(No.40971060)
中央高校基金资助项目(No.GK201504015)~~
关键词
血清糖类抗原19-9(CA19-9)
降维
分类回归树
空间分布
男性
carbohydrateantigen (CA19-9)
dimensionality reduction
classification regression tree
spatial distribution
adult male
作者简介
通信作者:葛淼,研究员,博士生导师. E-mail: gemiao@snnu.edu.cn.
