摘要
共晶技术在不改变药物活性成分的前提下可提高药物溶解度,从而改善药物吸收,提高生物利用度。共晶技术是改善难溶性黄酮类化合物溶解度的有效方法。其原理是共晶形成物与黄酮类化合物中羟基等基团通过氢键形成新的结晶形式,原有的晶格堆积和分子排列方式发生了变化。该文对黄酮类化合物的共晶研究进展及其共晶的物理化学性质进行综述,为黄酮类化合物在药物中的应用提供借鉴。
Cocrystal technology does not change the active ingredients,but improve solubility,thereby improve absorption and bioavailability. Cocrystal technology is an effective method for improving solubility of poorly water-soluble flavonoids.The principle is that hydrogen bonds are formed between hydroxyl groups in flavonoids and conformers to new crystalline,and the original lattice stacking and molecular arrangement changes. This review focus on the research progress of cocrystals of flavonoids and their physicochemical properties and bioavailability, which provide a good reference for the application of flavonoids cocrystals in pharmaceutical.
作者
陆祥
蒋成君
LU Xiang;JIANG Chengjun(Department of Pharmacy,Tonglu Traditional Chinese Hospital,Zhejiang Province,Tonglu 311500,China;School of Biological and Chemical Engineering,Zhejiang University of Science and Technology,Hangzhou 310023,China)
出处
《医药导报》
CAS
北大核心
2019年第7期921-926,共6页
Herald of Medicine
基金
杭州市科技计划项目(20163501Y132)
关键词
药物共晶
黄酮类化合物
理化性质
Pharmaceutical cocrystals
Flavonoids
Physicochemical properties
作者简介
陆祥(1975-),男,浙江杭州人,副主任中药师,学士,主要从事中药临床应用研究。ORCID:0000-0002-7380-1605,E-mail:451819948q@qq.com;通信作者:蒋成君(1981-),男,浙江杭州人,高级工程师,博士,主要从事制药工程研究。ORCID:0000-0001-9297-9399,电话:0571-85070383,E-mail:jcj312@163.com.
