摘要
目的:探讨纤维支气管镜灌洗联合胸腺五肽治疗支气管扩张症伴感染的疗效及对患者肺功能、炎性因子水平等的影响。方法:选取2015年1月至2017年1月保定市第二中心医院收治的支气管扩张症伴感染患者120例,以随机数字表法分为观察1组(常规治疗+纤维支气管镜吸痰)、观察2组(常规治疗+胸腺五肽)、观察3组(常规治疗+纤维支气管镜吸痰+胸腺五肽)和对照组(常规治疗),每组30例。对比四组患者的临床疗效、症状缓解时间、肺功能指标水平[1 s用力呼气容积占用力肺活量百分比(FEV_1/FVC)、呼气峰流速(PEF)及最大通气量(MBC)]、炎性因子水平[肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs-CRP)及白细胞介素8(IL-8)]及血气指标水平[动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)及pH]的差异。结果:观察1、2及3组患者的总有效率明显高于对照组,且观察3组患者明显高于观察1、2组,差异均有统计学意义(P<0.05)。治疗后,观察1、2及3组患者的咳嗽、咳痰缓解时间,体温复常时间,咯血停止时间及住院时间明显短于对照组,且观察3组患者明显短于观察1、2组,差异均有统计学意义(P<0.05)。治疗后,观察1、2及3组患者的FEV_1/FVC、PEF和MBC水平明显高于对照组,且观察3组患者明显高于观察1、2组,差异均有统计学意义(P<0.05)。治疗后,观察1、2及3组患者的TNF-α、hs-CRP及IL-8水平明显低于对照组,且观察3组患者明显低于观察1、2组,差异均有统计学意义(P<0.05)。治疗后,四组患者PaO_2、PaCO_2水平较治疗前明显升高,差异均有统计学意义(P<0.05)。结论:纤维支气管镜灌洗联合胸腺五肽治疗支气管扩张症伴感染的疗效显著,可有效改善患者的临床症状和肺功能,缓解炎症反应,安全可靠。
OBJECTIVE:To investigate the effects of bronchoscopic lavage combined with thymopentapeptide in treatment of bronchiectasis complicated with infection.METHODS:120 patients with bronchiectasis complicated with infection admitted into Baoding the Second Center Hospital from Jan.2015 to Jan.2017 were extracted,and were divided into the observation group 1 (routine treatment + bronchoscopic lavage),observation group 2 (routine treatment + thymus pentapeptide),observation group 3 (routine treatment + bronchoscopic lavage + thymus pentapeptide) and control group (routine treatment) via the random number table,with 30 cases in each group.The clinical efficacy,symptom relief time,and lung function indexes including 1 s forced expiratory volume occupancy spirometry percentage (FEV 1/FVC),peak expiratory flow rate (PEF) and maximum ventilation (MBC),inflammation factor levels including tumor necrosis factor α(TNF-α),high-sensitivity C-reactive protein (hs-CRP) and interleukin-8 (IL-8)] and blood gas levels including arterial oxygen partial pressure (PaO 2),arteries blood carbon dioxide partial pressure (PaCO 2) and pH were compared among four groups.RESULTS:The total effective rate of observation group 1,2 and 3 was significantly higher than that of the control group,and the observation group 3 was significantly higher than the observation group 1 and 2,with statistically significant differences ( P <0.05).After treatment,the relief time of cough and sputum,recovery timeof temperature,stopping time of hemoptysis and hospitalization time of the patients in observation group 1,2 and 3 were significantly shorter than those in the control group,and the observation group 3 was significantly shorter than the observation group 1 and 2,with statistically significant differences ( P <0.05).After treatment,the levels of FEV 1/FVC,PEF and MBC in the observation group 1,2 and 3 were significantly higher than those in the control group,and the observation group 3 was significantly higher than the observation group 1 and 2,the differences were statistically significant ( P <0.05).After treatment,the levels of TNF-α,hs-CRP and IL-8 in observation group 1,2 and 3 were significantly lower than those in the control group,and the levels in the observation group 3 were significantly lower than those in observation group 1 and 2,with statistically significant differences ( P <0.05).After treatment,the levels of PaO2 and PaCO2 in four groups were significantly higher than those before treatment,with statistically significant differences ( P <0.05).CONCLUSIONS:The efficacy of bronchoscopic lavage combined with thymopentapeptide in treatment of bronchiectasis complicated with infection is significant,which can effectively improve the patient’s clinical symptoms and lung function,relieve the inflammation,and be safe and reliable.
作者
董维维
李丹华
闫姗姗
肖剑
赵芳
姜国荣
李润浦
DONG Weiwei;LI Danhua;YAN Shanshan;XIAO Jian;ZHAO Fang;JIANG Guorong;LI Runpu(Dept.of Respiration,Baoding the Second Center Hospital,Hebei Baoding 072750,China;Dept.of Medical Image,Baoding the Second Center Hospital,Hebei Baoding 072750,China)
出处
《中国医院用药评价与分析》
2019年第5期542-545,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
保定市科学技术研究与发展指导计划项目(No.18ZF122)
关键词
胸腺五肽
纤维支气管镜
支气管扩张症伴感染
临床疗效
肺功能
炎症反应
Thymopentapeptide
Fiberoptic bronchoscope
Bronchiectasis complicated with infection
Clinical efficacy
Lung function
Inflammatory reactions
作者简介
董维维,主治医师,硕士。研究方向:支气管扩张、肺结核等肺部疾病的诊治。E-mail:dvkdg66@163.com.
