摘要
目的评价免疫调节疗法对脑瘫儿童神经运动发育的影响。方法将120例脑瘫患儿随机分为治疗组60例与对照组60例,治疗组在对照组的基础上给予免疫调节疗法,2组治疗均20d一疗程,疗程间间隔10d,连续治疗3个疗程,分别于治疗前、治疗3个疗程后采用Gesell发育测试、GMFM测试、体液免疫指标测定进行疗效评定。结果对照组治疗前后IgA、IgG、IgM、C3、C4水平差异无统计学意义(P>0.05);治疗组治疗前后IgA、IgG、C4水平差异有统计学意义(P<0.05);治疗后2组IgA、IgG水平比较差异有统计学意义(P<0.05)。2组治疗前后Gesell各能区发育商差异有统计学意义(P<0.05);治疗后2组Gesell各能区发育商比较差异有统计学意义(P<0.05)。2组感染例次比较差异有统计学意义(P<0.05)。2组治疗前后GMFM总分差异有统计学意义(P<0.05);2组治疗后GMFM总分比较差异有统计学意义(P<0.05)。结论配合使用免疫调节疗法可有效改善脑瘫患儿的免疫状态,更有利于提高脑瘫患儿粗大运动功能、Gesell测试发育商。
Objective To evaluate the effect of immunomodulatory therapy on neuromotor development in children with cerebral palsy. Methods 120 cases of children with cerebral palsy were randomly divided into treatment group of 60 cases and control group of 60 cases,treatment group were given immunomodulatory therapy on the basis of the control group,both groups are 20 days 1 treatment course,course of treatment between the interval of 10 days,continuous treatment 3 period of treatment,two groups of children with respectively before treatment,treatment after 3 course of adopting Gesell developmental test,determination of GMFM test,humoral immune index for curative effect evaluation. Results Before and after treatment,there was no significant difference in the levels of IgA,IgG,IgM,C3 and C4, P >0.05.There were statistical differences in the levels of IgA,IgG and C4 before and after treatment in treatment group, P <0.05;There was statistically significant difference between the treatment group and the control group after treatment in the levels of IgA/IgG, P <0.05.There was a statistical difference between the treatment group and the control group in Gesell after treatment, P <0.05.There was a statistical difference between the treatment group and the control group after treatment in Gesell test, P <0.05.There were statistical difference in infection cases between the treatment group and the control group after treatment, P <0.05;There were statistical difference in GMFM scores in both groups compared with before treatment, P <0.05.There were statistical difference in GMFM scores between treatment group and control group after treatment, P <0.05. Conclusion The combination of immunomodulation therapy can effectively improve the immune status of children with cerebral palsy,which is more beneficial to improve the gross motor function and Gesell test development quotient of children with cerebral palsy.
作者
张勇
翟红印
郭智宽
王军
ZHANG Yong;ZHAI Hongyin;GUO Zhikuan;WANG Jun(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用神经疾病杂志》
2019年第10期1052-1058,共7页
Chinese Journal of Practical Nervous Diseases
作者简介
张勇,Email:zhangyong005270@163.com.
