摘要
目的探讨甲状腺功能减退症(甲减)患者发生动脉粥样硬化(AS)的影响因素。方法:选取甲减患者152例,根据颈动脉内膜中层厚度(IMT)分为颈动脉正常组(A组)32例和AS组120例,AS组包括IMT增厚组(B组)27例和斑块形成组(C组)93例。收集受试者一般资料,检测促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、TC、TG、LDL-C、HDL-C,采用颈部血管超声检测颈部血管斑块,采用logistic回归分析甲减患者发生AS及AS严重程度的影响因素。结果AS组年龄[(70.65±5.34)岁vs (64.44±4.89)岁]、TSH[(13.83±9.01)mmol/L vs (6.00±4.01)mmol/L]、LDL-C[(3.84±1.02)mmol/L vs (2.52±1.39)mmol/L]明显高于A组,而HDL-C明显低于A组,差异有统计学意义(P<0.01);C组年龄和LDL-C最高,B组次之,A组最低(P<0.05);C组TSH、TC明显高于A组和B组,HDL-C明显低于A组和B组,差异有统计学意义(P<0.05)。logistic回归分析显示,TSH、年龄和LDL-C为甲减患者发生AS的危险因素(P<0.05,P<0.01),其中LDL-C对其影响较大(β=0.521);年龄、TSH和LDL-C为AS严重程度的危险因素(P<0.01),且LDL-C的影响程度较大(β=1.056)。结论TSH、年龄和LDL-C为甲减患者发生AS的独立危险因素,同时三者也是AS严重程度的影响因素,且LDL-C对AS的发生及严重程度的影响均较大。
Objective To study the risk factors for atherosclerosis in hypothyroidism patients.Methods One hundred and fifty-two hypothyroidism patients were divided into group A with normal carotid artery(n=32),group B with thickened carotid IMT(n=27)and group C with carotid plaques(n=93).Their general data(such as age,sex,BMI)were recorded,their serum levels of TSH,FT3,FT4,TC,TG,LDL-C,and HDL-C were measured,their carotid vascular plaques were detected by ultrasonography.The risk factors for atherosclerosis in hypothyroidism patients were analyzed by logistic regression analysis.Results The age was significantly older,the serum levels of TSH and LDL-C were significantly higher while those of HDL-C were significantly lower in groups B and C than in group A(P<0.01).The serum LDL-C level was the highest in group C followed by in groups B and A(P<0.05).The serum TSH and TC levels were significantly higher in group C than in groups A and B(P<0.05).Logistic regression analysis showed that age and serum levels of TSH and LDL-C were the risk factors for atherosclerosis(P<0.05,P<0.01),age and serum levels of TSH and LDL-C were related with the severity of atherosclerosis in hypothyroidism patients while the serum LDL-C level was closely relateed with atherosclerosis and the severity of atherosclerosis in hypothyroidism patients.Conclusion Age and serum levels of TSH and LDL-C are the independent risk factors for atherosclerosis and serum LDL-C level is closely related with the incidence and severity of atherosclerosis in hypothyroidism patients.
作者
韩菲
张媛媛
Han Fei;Zhang Yuanyuan(Shanxi Medical University No.1 School of Clinical Medicine,Taiyuan 030001,Shanxi Province,China)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2019年第6期626-628,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
作者简介
通信作者:张媛媛,Email:zyy3018@sohu.com.
