摘要
目的探究多索茶碱联合沙美特罗替卡松对慢性阻塞性肺疾病(COPD)患者炎性因子及血气分析指标的影响。方法选取2016年2月至2018年2月本院收治的COPD患者150例,随机分为观察组(75例)与对照组(75例)。对照组接受沙美特罗替卡松吸入治疗,在此基础上,观察组加施多索茶碱治疗。比较两组治疗效果、炎性因子、肺功能及血气分析指标水平的差异。结果观察组临床疗效明显高于对照组(P<0.05);治疗后,观察组炎性因子IL-5明显低于对照组,而IL-12则高于对照组(P<0.05);观察组血气指标PaO2明显高于对照组,而PaCO2则低于对照组(P<0.05);观察组肺功能指标FVC、FEV1、PEF均明显高于对照组(P<0.05)。结论多索茶碱联合沙美特罗替卡松可有效改善COPD患者肺功能及动脉血气,纠正体内Thl/Th2失衡,疗效显著,值得临床推荐。
Objective To investigate the effects of doxofylline combined with salmeterol and fluticasone on inflammatory factors and blood gas analysis in patients with chronic obstructive pulmonary disease (COPD). Methods 150 COPD patients admitted to our hospital from February 2016 to February 2018 were randomly divided into observation group (75 cases) and control group (75 cases). The control group was treated with salmeterol and fluticasone inhalation, and the observation group was treated with doxofylline. The therapeutic effect, inflammatory factors, pulmonary function and blood gas analysis indexes were compared between the two groups. Results The clinical efficacy of the observation group was significantly higher than that of the control group (P<0.05);after treatment, the inflammatory factor IL-5 of the observation group was significantly lower than that of the control group, while IL-12 was higher than that of the control group (P<0.05);the blood gas index PaO2 of the observation group was significantly higher than that of the control group, while PaCO2 was lower than that of the control group (P<0.05);the lung function index FVC, FEV1 and PEF of the observation group were significantly higher than that of the control group (P<0.05). Conclusion Doxofylline combined with salmeterol and fluticasone can effectively improve the pulmonary function and arterial blood gas of COPD patients, and correct the imbalance of Thl/Th2 in vivo. The curative effect is remarkable and worthy of clinical recommendation.
作者
王树宪
张坤
崔萍
Wang Shuxian;Zhang Kun;Cui Ping(Department of Respiration, Beihai Hospital, Yantai, Shandong, 255701, China)
出处
《当代医学》
2019年第16期33-36,共4页
Contemporary Medicine
关键词
慢性阻塞性肺疾病
多索茶碱
沙美特罗替卡松
Chronic obstructive pulmonary disease
Doxofylline
Salmeterol roticasone
