摘要
目的:探讨孟鲁司特用于小儿咳嗽变异性哮喘的临床疗效。方法:选取2016年6月至2018年6月赣南医学院第二附属医院及赣南医学院第一附属医院收治的咳嗽变异性哮喘患儿60例,以随机数字表法分为观察组和对照组,每组30例。对照组患儿给予常规治疗,观察组患儿在常规治疗的基础上加用孟鲁司特。观察两组患儿的哮喘症状控制情况、临床症状评分、临床症状缓解时间及临床疗效。结果:观察组患儿哮喘症状控制良好率为70.0%(21/30),明显优于对照组的43.3%(13/30),差异有统计学意义(P<0.05);治疗后,观察组、对照组患儿的临床症状评分分别为(1.25±0.53)、(2.57±0.41)分,均明显低于治疗前,且观察组患儿明显低于对照组,差异均有统计学意义(P<0.05);观察组患儿哮喘、肺部哮鸣音及咳嗽缓解时间明显短于对照组,差异均有统计学意义(P<0.05);观察组患儿的总有效率为96.7%(29/30),明显高于对照组的76.7%(23/30),差异有统计学意义(P<0.05)。结论:孟鲁司特治疗小儿咳嗽变异性哮喘,既可缓解患儿的临床症状,又可提高临床疗效,提高哮喘症状的控制水平。
OBJECTIVE: To probe into the clinical efficacy of montelukast in treatment of cough variant asthma in children. METHODS: 60 children with cough variant asthma admitted into the Second Affiliated Hospital of Gannan Medical University and the First Affiliated Hospital of Gannan Medical University from Jun. 2016 to Jun. 2018 were selected and divided into observation group and control group via random number table, with 30 cases in each group. The control group was given conventional therapy, while the observation group was treated with montelukast based on the control group. The control rate of asthma, clinical symptom score, clinical symptom relief time and efficacy of both groups were observed. RESULTS: The control rate of asthma of observation group was 70.0%(21/30), which was significantly higher than that of the control group(43.3%,13/30), with statistically significant difference(P<0.05);after treatment, the clinical symptom scores of observation group and control group were respectively(1.25±0.53) points and(2.57±0.41) points, which were significantly lower than those of before treatment, and that of the observation group was significantly lower than the control group, with statistically significant differences(P<0.05);the relief time of asthma, wheeze and cough of observation group were significantly shorter than those of the control group, with statistically significant differences(P<0.05);the total effective rate of observation group was 96.7%(29/30), which was significantly higher than that of the control group(76.7%, 23/30), with statistically significant difference(P<0.05). CONCLUSIONS: The application of montelukast in treatment of cough variant asthma in children can relieve clinical symptoms, improve clinical efficacy and promote the control rate of asthma.
作者
黄文生
钟小明
谢海燕
肖洪亮
杜良忠
HUANG Wensheng;ZHONG Xiaoming;XIE Haiyan;XIAO Hongliang;DU Liangzhong(Dept.of Pediatrics, the Second Affiliated Hospital of Gannan Medical University, Jiangxi Ganzhou 341000, China;Dept.of Pediatrics, the First Affiliated Hospital of Gannan Medical University, Jiangxi Ganzhou 341000, China)
出处
《中国医院用药评价与分析》
2019年第4期443-444,447,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
作者简介
黄文生,主治医师。研究方向:儿童呼吸、儿童消化。E-mail:bingzai808@163.com.
