摘要
目的观察白细胞介素1(IL-1)、白细胞介素6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)联合检测对胎膜早破并发绒毛膜羊膜炎(HCA)的诊断价值。方法选取2017年1月—2018年9月我科收治的胎膜早破患者85例,按照是否合并HCA分为A组50例和B组35例,并选择同期健康妊娠者50例作为C组,测定3组IL-1、IL-6、PCT、CRP水平。结果 A组IL-1、IL-6、PCT、CRP水平高于B组和C组,且B组高于C组(P<0.05)。四项指标联合检测特异性和阳性预测值均高于其他单一方法(P<0.05)。结论联合检测血IL-1、IL-6、PCT、CRP水平对门诊产前筛查有重要意义,能防止临床对胎膜早破并发HCA的漏诊。
Objective To observe values of combined detection of interleukin-1 (IL-1), interleukin-6 (IL-6), procalcitonin (PCT) and C-reactive protein (CRP) in diagnosis of patients with premature rupture of membranes complicated with chorioamnionitis. Methods A total of 85 patients with premature rupture of membranes admitted during January 2017 and September 2018 were divided into group A ( n =50) and group B ( n =35) according to whether or not combination of chorioamnionitis, and other 50 healthy pregnant women at the same period were selected as group C. Levels of IL-1, IL-6, PCT and CRP were detected among three groups. Results IL-1, IL-6, PCT and CRP levels in group A were significantly higher than those in group B and C, and the levels in group B were significantly higher than those in group C ( P <0.05). Specificity and positive predictive values by combined detection of the four indicators were significantly higher than those by each single method ( P <0.05). Conclusion Combined detection of serum IL-1, IL-6, PCT and CRP levels is important for prenatal screening in outpatient clinics, and it may prevent missed diagnosis of patients with premature rupture of membranes complicated with chorioamnionitis.
作者
王俊兰
朱艳红
周新
王玉贞
辛娜
WANG Jun-lan;ZHU Yan-hong;ZHOU Xin;WANG Yu-zhen;XIN Na(Department of Obstetrics, Maternal and Child Health Hospital of Cangzhou City, Cangzhou, Hebei 061001, China;Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Shijiazhuang, Shijiazhuang 050000, China)
出处
《解放军医药杂志》
CAS
2019年第5期93-95,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
河北省中医药管理局科研计划项目(2018242)
沧州市科技局科技支撑计划项目(162302013)
