摘要
目的探析肺癌辅助诊断中肿瘤标志物与凝血指标的诊断价值。方法将2016年2月～2018年11月我院收治的48例肺癌患者纳入研究组,将同期48例健康体检人员纳入对照组,通过电化学发光仪和全自动血凝分析仪检测患者肿瘤标志物和凝血指标,肿瘤标志物包括鳞状细胞癌相关抗原(SCC)、癌胚抗原(CEA)、细胞角蛋白19(CYFRA21-1)和神经元特异性烯醇化酶(NSE);凝血指标包括D-二聚体(D-dimer)、纤维蛋白原(FIB)、活血部分凝血活酶时间(APTT)、凝血酶时间(TT)及血浆凝血酶原时间(PT)。结果在SCC、CYFRA21-1、CEA及NSE方面,研究组均高于对照组,差异存在统计学意义(P<0.05);研究组TT低于对照组,而D-dimer、FIB高于对照组,差异均有统计学意义(P<0.05);两组APTT及PT分别比较,差异均无统计学意义(P>0.05)。结论根据CEA、CYFRA21-1、NSE及FIB指标水平,有助于肺癌疾病诊断准确率的提高,根据肿瘤标志物及凝血指标数值,有助于判断肺癌发展状况。
Objective To investigate the diagnostic value of tumor markers and coagulation parameters in the diagnosis of lung cancer. Methods 48 patients with lung cancer admitted to our hospital from February 2016 to November 2018 were enrolled in the study group. 48 healthysubjects were included in the control group, and the tumor markers were detected by electrochemiluminescence and automatic hemagglutination analyzer. And coagulation indicators, tumor markers including squamous cell carcinoma associated antigen (SCC), carcinoembryonic antigen (CEA), cytokeratin 19 (CYFRA21-1) and neuron specific enolase (NSE);coagulation indicators include D-dimer, fibrinogen (FIB), viable partial thromboplastin time (APTT), thrombin time (TT), and plasma prothrombin time (PT). Results In the SCC, CYFRA21-1, CEA and NSE, the study group was higher than the control group, the difference was statistically significant (P<0.05);the study group TT was higher than the control group, and the D-dimer was lower than the control group, the difference All of them were statistically significant (P<0.05). There were no significant differences in APTT and PT between the two groups (P>0.05). Conclusion According to CEA, CYFRA21-1, NSE and FIB levels, it can help to improve the accuracy of lung cancer diagnosis. According to the tumor markers and coagulation index values, it can help to judge the development of lung cancer.
作者
杨寿林
宋庆志
吴路发
黎虹妤
YANG Shou-lin;SONG Qing-zhi;WU Lu-fa;LI Hong-yu(Department of Laboratory,Ganxian District People's Hospital,Ganzhou 341100,Jiangxi,China)
出处
《医学信息》
2019年第7期168-169,共2页
Journal of Medical Information
关键词
肺癌
凝血指标
肿瘤标志物
Lung cancer
Coagulation index
Tumor markers
作者简介
杨寿林(1973.2-),男,江西赣州人,本科,主管技师,主要从事实验室质量管理及临床生化和发光免疫方面检验.
