摘要
目的分析和探索急性心肌梗死患者应用心肌钙蛋白T联合氨基末端脑钠肽前体检测在其发病早期方面的诊断价值。方法抽取2014年3月—2017年10月43例在该院进行急性心肌梗死诊治的患者并作为研究组,同时选取41例同期在该院接受诊治的非急性心肌梗死患者并作为参照组,检测氨基末端脑钠肽前体与心肌钙蛋白T。结果研究组患者氨基末端脑钠肽前体为(482.36±63.24)pg/mL、心肌钙蛋白T水平为(0.61±0.12)ng/mL,参照组患者分别为(176.12±57.82)pg/mL、(0.09±0.05)ng/mL,研究组患者氨基末端脑钠肽前体高于参照组,2组差异有统计学意义(t=14.099 1,P=0.013 7)心肌钙蛋白T水平明显较参照组患者高,2组差异有统计学意义(t=10.027 3,P=0.029 2)。氨基末端脑钠肽前体急性心肌梗死检测特异度为75.61%,敏感度为88.37%,心肌钙蛋白T检测特异度为80.49%,敏感度为83.72%,氨基末端脑钠肽前体与心肌钙蛋白T水平联合检测特异度为92.68%,敏感度为90.70%,氨基末端脑钠肽前体与心肌钙蛋白T水平联合检测特异度高于氨基末端脑钠肽前体(χ~2=9.007 2,P=0.018 3),敏感度高于氨基末端脑钠肽前体(χ~2=11.076 5,P=0.027 0),联合检测特异度高于心肌钙蛋白T(χ~2=8.654 2,P=0.014 2),敏感度高于心肌钙蛋白T(χ~2=13.524 4,P=0.029 1)。结论急性心肌梗死患者应用心肌钙蛋白T联合氨基末端脑钠肽前体检测具有较高的敏感性和特异性,能够及早发现病情,方便临床医生采取科学诊治措施,对于控制病情发展可发挥积极作用。
Objective To analyze and explore the diagnostic value of myocardial troponin T combined with amino terminal pro-brain natriuretic peptide in patients with acute myocardial infarction. Methods From March 2014 to October2017, 43 patients who underwent acute myocardial infarction in our hospital were enrolled as the study group. 41 patients with non-acute myocardial infarction who were treated in our hospital at the same time were selected as the reference group. The amino terminal brain natriuretic peptide precursor and cardiac troponin T were detected. Results The amino-terminal pro-brain natriuretic peptide in the study group was(482.36±63.24)pg/mL, the cardiac troponin T level was(0.61±0.12)ng/mL, and the reference group was(176.12±57.82)pg/mL,(0.09±0.05)ng/mL, the amino-terminal pro-brain natriuretic peptide in the study group was higher than the reference group, and the difference between the two groups was statistically significant(t=14.099 1, P=0.013 7). The myocardial troponin T level was significantly higher than that of the reference group, the difference between the two groups was statistically significant(t=10.027 3, P=0.029 2). The specificity of detection of acute myocardial infarction with amino terminal brain natriuretic peptide was75.61%, the sensitivity was 88.37%, the specificity of myocardial troponin T detection was 80.49%, the sensitivity was83.72%, and the amino terminal brain natriuretic peptide precursor and myocardial calcium specificity of protein T level combined detection was 92.68%, and the sensitivity was 90.70%. The specificity of combined detection of amino terminal brain natriuretic peptide and cardiac troponin T level was higher than that of amino terminal brain natriuretic peptide(χ^2=9.007 2, P= 0.018 3), the sensitivity is higher than the amino terminal brain natriuretic peptide precursor(χ^2=11.076 5, P=0.027 0), the combined detection specificity is higher than the cardiac troponin T(χ^2=8.654 2, P =0.014 2), the sensitivity is higher than the myocardial calcium Protein T(χ^2=13.524 4, P=0.029 1). Conclusion The application of cardiac troponin T combined with amino terminal pro-brain natriuretic peptide detection in patients with acute myocardial infarction has high sensitivity and specificity, can detect the disease early, and is convenient for clinicians to take scientific diagnosis and treatment measures, which can play an active role in controlling the development of the disease.
作者
钱小丽
QIAN Xiao-li(Department of Emergency Medicine, Second People's Hospital of Qujing City, Qujing, Yunnan Province, 655000 China)
出处
《系统医学》
2019年第3期45-47,共3页
Systems Medicine
关键词
心肌钙蛋白T
氨基末端脑钠肽前体
急性心肌梗死
早期诊断
Cardiac troponin T
Amino terminal brain natriuretic peptide precursor
Acute myocardial infarction
Early diagnosis
作者简介
钱小丽(1984-),女,云南曲靖人,本科,主治医师,主要从事急诊内科急危重患者的诊治及抢救工作.
