摘要
丙戊酸钠是癫痫治疗的主要药物之一,疗效好、抗癫痫谱广、经济性佳、浓度监测方法成熟,在我国应用非常广泛。然而,丙戊酸钠与多种药物联合使用,代谢会收到影响,出现药物间相互作用。碳青霉烯类就是其中一类可导致丙戊酸钠浓度降低的药物,因此,在临床药物治疗过程中,必须使用这类药物与丙戊酸钠联合时,需严密监护血药浓度及症状。此时,临床药师全程药学监护就能起到非常重要的作用,能为患者治疗的合理性、有效性、安全性保驾护航。
Sodium valproate is one of the main drugs for epilepsy treatment,which has good efficacy,wide antiepileptic spectrum,good economy and mature concentration monitoring method.However,when sodium valproate being used in combination with a variety of drugs,metabolism is affected and drug interactions occurs.Carbapenems are one of the drugs that can reduce the concentration of sodium valproate.Therefore,it is necessary to use these drugs in combination with sodium valproate during clinical drug treatment,and the blood concentration and symptoms should be closely monitored.Clinical pharmacists can play a very important role in the whole process of pharmaceutical monitoring,and can escort the rationality,effectiveness and safety of patients'treatment then.
作者
朱彩红
赖莎
ZHU Caihong;LAI Sha(The Fifth Affiliated Hospital of Southern Medical University,Guangzhou 500900,China;The First Affiliated Hospital ofGuangdong Pharmaceutical University,Guangzhou 510800,China)
出处
《中国医药科学》
2019年第2期251-253,共3页
China Medicine And Pharmacy
关键词
美罗培南
丙戊酸钠
血药浓度
相互作用
Meropenem
Sodium valproate
Plasma concentration
Interreaction
作者简介
通讯作者:赖莎.
