摘要
目的:研究肥胖儿童血清上皮型脂肪酸结合蛋白(E-FABP)与体内糖脂代谢、微炎症反应的相关性。方法:选择因单纯性肥胖在我院内分泌科就诊的儿童作为研究的肥胖组,另取同期在我院健康体检的儿童作为对照组。采集血清并测定E-FABP、糖脂代谢指标、炎症细胞因子的含量,采集外周血并测定胰岛素信号分子的表达量。结果:肥胖组儿童血清中E-FABP的含量显著高于对照组;血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、瘦素(Leptin)、趋化素(Chemerin)、胰岛素(F-INS)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、可溶性细胞间黏附分子-1(sICAM-1)、单核细胞趋化蛋白1(MCP1)的含量显著高于对照组且与血清中E-FABP的含量呈正相关,血清中高密度脂蛋白胆固醇(HDL-C)、脂联素(APN)、补体C1q/肿瘤坏死因子蛋白12(CTRP12)、网膜素-1(Omentin-1)的含量以及外周血中胰岛素受体底物1(IRS1)、IRS2、葡萄糖转运蛋白-4(GLUT-4)的表达强度显著低于对照组且与血清中E-FABP的含量呈负相关。结论 :肥胖儿童血清中E-FABP的过度分泌与糖脂代谢紊乱、微炎症反应异常激活密切相关。
Objective:To study the correlation of serum epithelial fatty acid binding protein(E-FABP)with glucose and lipid metabolism and micro inflammatory reaction in obese children.Methods:Children diagnosed as simple obesity in endocrinology department of my hospital during June 2014-August 2017 were selected as the obese group,and the health examinationchildren were selected as the control group.The serum was collected and the levels of E-FABP,glucose and lipid metabolism and inflammatory cytokines were determined,peripheral blood was collected and the expression level of insulin signal molecules were measured.Results:Serum E-FABP content of obese groupwas significantly higher than that in the control group;serum total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),Leptin,Chemerin,F-INS,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-β),interleukin-6(IL-6),soluble intercellular adhesion molecule-1(sICAM-1)and monocyte chemoattractant protein 1(MCP1)of obese group were significantly higher than thosein the control group and positively correlated with serum E-FABP content;serum high density lipoprotein cholesterol(HDL-C),lipoprotein(APN),and C1q/tumor necrosis factor-related proteins 12(CTRP12),Omentin-1 and the expression intensity of insulin receptor substrate 1(IRS1),IRS2,glucose transporter-4(GLUT-4)in peripheral blood were significantly lower than those of the control group and negatively correlated with serum E-FABP content.Conclusion:Excessive secretion of E-FABP in obese children is closely related to the disorder of glucose and lipid metabolism and the activation of micro inflammatory reaction.
作者
蒋秀琳
JIANG Xiu-lin(Zaoyang First People's Hospital,Hubei,431600,China)
出处
《海南医学院学报》
CAS
2019年第3期233-236,共4页
Journal of Hainan Medical University
基金
湖北省自然科学基金(2016CFB368)~~
关键词
肥胖
上皮型脂肪酸结合蛋白
糖脂代谢
炎症反应
Obesity
Epithelial fatty acid binding protein
Glucose and lipid metabolism
Inflammatory reaction
作者简介
蒋秀琳(1969-),女,湖北枣阳人,本科,主治医师,E-mail:jv74419@163.com。
