摘要
目的探讨乳腺癌新辅助治疗病理完全缓解的影响因素及预后。方法回顾性分析2010年6月12日～2015年6月12日新疆维吾尔自治区人民医院收治的150例乳腺癌患者的临床资料,所有患者均为女性,均接受新辅助化疗,对其临床资料、病理资料、随访资料进行收集分析,探讨病理完全缓解的影响因素及预后。结果患者体质量、哺乳时间、化疗周期、肿瘤大小、雌激素受体(ER)、孕激素受体(PR)、雌/孕激素受体(ER/PR)、分子分型均为影响新辅助治疗病理完全缓解的单因素,经Logistic回归分析可知,体质量、ER均为影响新辅助治疗病理完全缓解的独立预测因素,新辅助治疗病理完全缓解对乳腺癌患者生存无明显影响。结论对于乳腺癌患者,其体质量、ER均为乳腺癌新辅助治疗病理完全缓解的影响独立预测因素,而且新辅助治疗病理完全缓解与乳腺癌患者的预后生存无明显影响。
Objective To explore the influencing factors and prognosis of pathological complete remission of neoadjuvant therapy for breast cancer.Methods The clinical data of 150 patients with breast cancer admitted to People′s Hospital of Xinjiang Uygur Autonomous Region from June 12,2010 to June 12,2015 were retrospectively analyzed.All of them were women who received neoadjuvant chemotherapy.The clinical data,pathological data and follow-up data were collected and analyzed to explore the influencing factors and prognosis of pathological complete remission.Results Body mass,lactation time,chemotherapy cycle,tumor size,ER,PR,ER/PR and molecular typing were all single factors affecting the complete remission of neoadjuvant therapy.Complete remission has no significant effect on survival of breast cancer patients.Conclusion For breast cancer patients,body mass and ER are independent predictors of pathological complete remission of neoadjuvant therapy,and the pathological complete remission of neoadjuvant therapy has no significant impact on prognosis and survival of breast cancer patients.
作者
李帅
马文静
马晶
唐晖
LI Shuai;MA Wen-jing;MA Jing;TANG Hui(Clinical Inspection Center,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,China;Department of Clinical Laboratory,Traditional Chinese Medicine Hospital of Urumqi City in Xinjiang Uygur Autonomous Region,Urumqi 830002,China)
出处
《中国当代医药》
2019年第5期95-97,共3页
China Modern Medicine
关键词
影响因素
预后
新辅助治疗
乳腺癌
病理
完全缓解
Influencing factors
Prognosis
Neoadjuvant therapy
Breast cancer
Pathology
Complete remission
