摘要
目的探讨肝脾CT值比值和扩散加权成像ADC值的相关性,以及扩散加权成像ADC值对NAFLD病变程度的诊断价值。方法选取2016年3月～2017年8月我院收治的NAFLD患者96例,分为轻度组(30例)、中度组(34例)和重度组(32例),另选健康成人作为对照组(30例)。比较健康受试者与NAFLD患者的ADC的差异,比较NAFLD各组间ADC值的差异;分析肝脾CT值比值与ADC值的相关性以及两者与LDL-C的相关性。结果研究组的ADC值明显小于对照组,且差异有统计学意义(P<0.05)。轻度、中度和重度组的ADC值明显小于对照组(P<0.05)。轻度、中度及重度组组间差异有统计学意义(P<0.05);Pearson相关分析显示,肝脾CT值比值与ADC值呈显著正相关(P<0.01),肝脾CT值比值、ADC值与血清LDL-C呈负相关性(P<0.05)。结论 NAFLD病变程度加重,肝脾CT值比值随之变小,而ADC值也相应降低,磁共振扩散加权成像作为一项无创、定量诊断方法,在NAFLD病变程度分级上具有临床价值。
Objective To investigate the correlation between liver and spleen CT ratio and diffusion-weighted imaging ADC value,and the diagnostic value of diffusion-weighted imaging(ADC)in the severity of NAFLD.Methods 96 NAFLD patients admitted in our hospital from March 2016 to August 2017 were selected and divided into mild group(n=30),moderate group(n=34)and severe group(n=32).The healthy adults were selected as control group(n=30).The difference in ADC between healthy subjects and NAFLD patients was compared.Difference in ADC value between the NAFLD groups was compared.Correlation between liver and spleen CT value ratio and their correlation with LDL-C were analyzed.Results The ADC value of the study group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The ADC values in the mild,moderate,and severe groups were significantly lower than those in the control group(P<0.05),and the difference among mild,moderate,and severe groups was statistically significant(P<0.05).Pearson correlation analysis showed that the ratio of liver and spleen CT values was significantly positively correlated with ADC values(P<0.01),and the ratio of liver and spleen CT values,the ADC value was negatively correlated with serum LDL-C(P<0.05).Conclusion With the aggravation of NAFLD lesion degree,the ratio of liver and spleen CT values become smaller,and the ADC value decreases accordingly.As a non-invasive and quantitative diagnostic method,MR diffusion-weighted imaging has clinical value in the classification of NAFLD lesions.
作者
胡海华
赵红星
HU Haihua;ZHAO Hongxing(Department of Radiology,Huzhou First People's Hospital in Zhejiang Province,Huzhou 313000,China)
出处
《中国现代医生》
2019年第2期95-98,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2018KY774)
浙江省湖州市科技计划项目(2016GYB04)
关键词
非酒精性脂肪肝
CT值
扩散加权成像
相关性
低密度脂蛋白胆固醇
Non-alcoholic fatty liver
CT value
Diffusion-weighted imaging
Correlation
Low-density lipoprotein cholesterol
作者简介
通讯作者:赵红星
