摘要
目的观察依那普利联合叶酸治疗老年H型高血压病对患者炎性因子及血管内皮功能的影响。方法选取老年H型高血压病120例,采用随机数字表法随机将其分为观察组和对照组两组各60例,观察组采用依那普利联合叶酸治疗,对照组采用依那普利治疗,两组均治疗12周。观察比较两组治疗前及治疗12周后收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)及血清同型半胱氨酸(homotypic cysteine,Hcy)、炎性因子、血管内皮功能指标水平。结果治疗前,两组SBP、DBP及血清Hcy、肿瘤坏死因子α(tumor necrosis factor,TNF-α)、超敏C反应蛋白(hypersensitive c reactive protein,hs-CRP)、内皮素1(endothelin,ET-1)、一氧化氮(nitric oxide,NO)水平比较差异无统计学意义(P> 0. 05)。治疗12周后,两组SBP、DBP及血清Hcy、TNF-α、hs-CRP、ET-1水平均显著低于治疗前,血清NO水平显著高于治疗前,差异有统计学意义(P <0. 05)。治疗12周后,观察组SBP、DBP及血清Hcy、TNF-α、hs-CRP、ET-1水平均显著低于对照组,血清NO水平显著高于对照组,差异有统计学意义(P <0. 05)。结论依那普利联合叶酸治疗老年H型高血压病可降低患者血压及血清Hcy水平,抑制炎性因子释放,改善血管内皮功能。
Objective To investigate the effect of Enalapril combined with Folic Acid Tablets on inflammatory factors and vascular endothelial function in elderly patients with H-type hypertension.Methods A total of 120 cases of elderly patients with H-type hypertension were randomly divided into control group(n=60)and observation group(n=60),according to random number table.The patients in the control group were treated with Enalapril Maleate Tablets,and those in the observation group were treated with Folic Acid Tablets combined with Enalapril Maleate Tablets.The course of treatment was 12 weeks.The systolic blood pressure(SBP),diastolic blood pressure(DBP)and serum homocytosine(Hcy),inflammatory factors and endothelial function index levels were compared before treatment and 12 weeks after treatment.Results There was no significant difference in the levels of SBP,DBP,Hcy,tumor necrosis factor(TNF-α),hypersensitive c reactive protein(hs-CRP),endothelin(ET-1)and nitric oxide(NO)in the two groups before treatment(P >0.05).At 12 weeks after treatment,the levels of SBP,DBP,Hcy,TNF-α,hs-CRP and ET-1 in both groups were significantly lower than those before treatment,whereas the serum NO level was significantly higher than that before treatment(P<0.05).At 12 weeks after treatment,the levels of SBP,DBP,Hcy,TNF-α,hs-CRP and ET-1 in the observation group were significantly lower than those in the control group,while the serum NO level was significantly higher than that in the control group(P<0.05).Conclusion In the treatment of the elderly with H-type hypertension,folic Acid Tablets combined with Enalapril can effectively reduce the blood pressure and Hcy level,inhibit the release of inflammatory factors and improve vascular endothelial function.
作者
文海英
赖小文
黄楷森
WEN Hai-ying;LAI Xiao-wen;HUANG Kai-sen(Department of Internal Medicine,Guanghan Orthopaedic Hospital,Sichuan,Guanghan 618300,China;Department of Cardiology,Guanghan People's Hospital,Sichuan,Guanghan 618300,China;Department of Cardiology,People's Hospital of Deyang City,Sichuan,Deyang 618000,China)
出处
《临床误诊误治》
2019年第2期22-26,共5页
Clinical Misdiagnosis & Mistherapy
基金
四川省卫生厅科研课题(150955)
关键词
高血压
依那普利
叶酸
炎性因子
血管内皮功能
Hypertension
Enalapril
Folic acid
Inflammatory factors
Vascular endothelial function
