摘要
目的建立西安地区0～12岁健康儿童血清S100蛋白的参考区间。方法选择2018年7月1日起在西安市儿童医院儿保科健康体检的125例不同年龄、性别分布的健康儿童,使用西安金磁纳米生物技术公司的磁定量免疫分析仪及其配套试剂测定血清S100蛋白水平。按照《中华人民共和国卫生行业标准WST-402-2012》文件所规定的方法,分析、建立并验证血清S100蛋白参考区间。结果西安地区0～12岁儿童血清S100蛋白水平呈偏态分布;不同性别间血清S100蛋白差异无统计学意义(P>0.05);不同年龄分组间血清S100蛋白差异无统计学意义(P>0.05);0～12岁儿童血清S100蛋白参考区间为:血清S100≤270.375 5pg/ml。结论实验室根据现有检测系统,建立了西安地区0～12岁健康儿童的血清S100蛋白参考区间,为临床疾病的诊断奠定了基础。
Objective To establish biology reference interval of serum protein S100 level in children between 0 and 12 years old in Xi’an.Methods Serum protein S100 level were dectected in 125 children from 0~12 years by GoldMag Lateral Flow Immunoassy analysis system.The S100 protein reference interval was analyzed,established and validated in accordance with the methods specified in the"People’s Republic of China Health Industry Standard WST-402-2012".Results Serum S100 protein levels in children aged 0~12 years in Xi’an were skewed.And without significant difference between different genders and ages(P >0.05).The reference range of serum S100 protein in children aged 0~12 was S100≤270.375 5 pg/ml.Conclusion Based on the existing detection system,the laboratory established a serum S100 protein reference interval for children aged 0~12 years,which laid the foundation for the diagnosis of clinical diseases.
作者
吴爽
张书婉
张涛元
陈露
曹三成
李俏
WU Shuang;ZHANG Shu-wan;ZHANG Tao-yuan;CHEN Lu;CAO San-cheng;LI Qiao(Department of Clinical Laboratory,Xi’an Children’s Hospita l,Xi’an,710003,China;Rizhao Heart Hospital,Shandong Rizhao 276800,China)
出处
《现代检验医学杂志》
CAS
2019年第1期124-126,共3页
Journal of Modern Laboratory Medicine
基金
西安市科技局项目(J201702019Ⅱ热休克蛋白HSP70与HBV PreS1作用并介导HBV黏附入侵的相关研究)
关键词
S100蛋白
儿童
参考区间
颅脑损伤
protein S100
children
biological reference interval
brain injury
作者简介
吴爽(1990-),女,硕士,初级检验师,研究方向:HBV黏附相关性研究,E-mail:395480829@qq.com;通讯作者:李俏(1988-),女,博士,中级检验师,研究方向:病原微生物,E-mail:wschildren@163.com.
