摘要
目的探究血糖控制不佳的2型糖尿病患者接受利拉鲁肽治疗对其胰岛β细胞功能以及血糖波动的影响。方法 2型糖尿病患者100例根据其治疗方案的不同分为对照组和试验组,每组50例。对照组在基础治疗之上实施二甲双胍治疗,试验组则实施利拉鲁肽治疗,观察2组治疗前后血糖[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb A1c)]、体重指数(BMI)、胰岛素水平(FIns)、血压、血脂[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、稳态模型胰岛素β细胞分泌指数(HOMA-β)、稳态模型胰岛素抵抗指数(HOMA-IR)水平和胰岛素用量]。结果 2组2型糖尿病患者的血糖水平均较治疗前明显改善,其中试验组血糖水平改善程度明显优于对照组(P <0. 05);试验组2型糖尿病患者治疗后的BMI、FIns水平均较治疗前改善,且明显优于对照组(P <0. 05)。2组治疗前后的血压水平比较,差异无统计学意义(P> 0. 05); 2组治疗前后的TC、HDL-C、LDL-C水平比较,差异无统计学意义(P> 0. 05)。其中试验组治疗后的TG水平明显较治疗前改善,且优于对照组(P <0. 05); 2组2型糖尿病患者治疗后的HOMA-β、HOMA-IR均较治疗前改善,胰岛素使用量均明显降低,其中试验组HOMA-β、HOMA-IR改善程度、胰岛素使用量降低量均优于对照组(P <0. 05)。结论血糖控制不佳的2型糖尿病患者接受利拉鲁肽治疗,能够有效对其血糖水平进行控制,对其胰岛素抵抗进行改善,促进其胰岛β细胞功能的增强。
Objective To investigate the effects of liraglutide on the function of beta cell of islet and blood glucose fluctuation in patients with type 2 diabetes mellitus with poor blood glucose control.Methods A total of 100 patients with type 2 diabetes mellitus were enrolled as research objects,according to different therapeutic schedules,these patients were divided into control group and experimental group,with 50 patients in each group.The patients in both groups were treated by basic treatment,and the patients in control group were treated by oral diformin,however,the patients in experimental group were treated by oral liraglutide.The blood glucose levels including FBG,2 hPBG,HbA1c,and BMI,Fins,blood pressure,blood lipid including TC,TG,HDL-C,LDL-C,and HOMA-β,HOMA-IR and insulin dosage before and after treatment were observed and compared between the two groups.Results The blood glucose levels of patients in both groups were significantly improved compared,as compared with those before treatment,moreover,the improvement degree in experimental group was superior to that in control group(P<0.05).After treatment the levels of BMI and FIns in experimental group were superior to those in control group(P<0.05).There were no significant differences in the blood pressure levels in both groups before and after treatment(P >0.05).Moreover there were no significant differences in the levels of TC,HDL-C and LDL-C in both groups before and after treatment(P >0.05).After treatment the TG levels in experimental group were superior to those in control group(P<0.05).After treatment the levels of HOMA beta,HOMA IR were obviously improved in both groups,and insulin dosage was significantly decreased,moreover,which in experimental group were superior to those in control group(P<0.05).Conclusion The liraglutide can effectively control the blood glucose levels in patients with type 2 diabetes mellitus with poor blood glucose control,and improve insulin resistance to promote islet beta cell function.
作者
王雅清
WANG Yaqing(The Second Hospital of Baoding City,Hebei,Baoding 071000,China)
出处
《河北医药》
CAS
2019年第2期247-250,共4页
Hebei Medical Journal
关键词
利拉鲁肽
2型糖尿病
胰岛Β细胞
血糖波动
liraglutide
type 2 diabetes
islet beta cells
blood glucose fluctuation
