摘要
目的基于"识毒-用毒-防毒-解毒"警戒思想,梳理《本草纲目》中收录虫部中药的警戒信息,为现代临床合理应用虫类药提供参考。方法基于Excel 2016提取《本草纲目》(金陵版点校本)中记载虫部中药的毒性、性味、适应证、炮制、配伍等记载,按照识毒、用毒、防毒、解毒等分类统计。结果在收录的131种虫部药中,41种具有毒性,以有毒占比最多,为68.3%,普遍具有辛寒、辛温之性。虫部有毒药物入药多为炮制品,且多以外用为主。部分虫部有毒中药有明确的减毒、解毒方法。结论虫部药的防毒、减毒措施丰富,对现代具有借鉴作用。
Objective Based on the whole pharmacovigilance theoretical frame that is formed by cognition,application,prevention and rescue of drug toxicity,the warning information of the Chinese medicine in the Compendium of Materia Medica was combed in order to provide ideas for the rational use of insect drugs in modern clinical practice. Methods Based on the Excel2016extraction(Jinling-edition)of the toxicity,flavor-nature,indications,processing and compatibility of the Chinese medicine recorded in the Compendium of Materia Medica,categorical statistics were used according to the classification of drug recognition,drug use,toxcity defense and detoxification. Results Among the131kinds of insect drugs,41species were indentified toxic,and the category of toxic ones was found the most,accounting for68.3%.It has been found that most insect drugs were processed products mainly for external use and some toxic Chinese medicines had specific methods of detoxification and rescue of drug toxicity. Conclusion The insect drugs are effective for the prevention of drug toxicity and detoxification,and can be used as reference in modern times.
作者
郭鹏杰
王笑
张晓朦
张冰
林志健
吴嘉瑞
GUO Pengjie;WANG Xiao;ZHANG Xiaomeng;ZHANG Bing;LIN Zhijian;WU Jiarui(School of Chinese Pharmacy,Beijing University of Chinese Medicine, Beijing 100029,China)
出处
《医药导报》
CAS
北大核心
2019年第1期41-44,共4页
Herald of Medicine
基金
国家自然科学基金资助项目(8167140621)
北京中医药大学新奥"颜正华临床中药学思想的挖掘与传承模式研究"项目(1000062720062/009/001)
关键词
本草纲目
虫部
有毒中药
药物警戒
Compendium of Materia Medica
Insect classification
Toxic Chinese medicines
Pharmacovigilance
作者简介
郭鹏杰(1993-),男,河南鹤壁人,在读硕士,研究方向:中药不良反应与药物警戒理论、中药合理应用。ORCID:0000-0002-8681-3787。电话:(0)18801315991,E-mail:guopengjie66@163.com;通信作者:林志健(1983-),男,北京人,副教授,硕士生导师,研究方向:中药不良反应与药物警戒理论、中药合理应用。电话:010-64286335,E-mail:linzhijian83@126.com。
