摘要
目的探讨并发心房颤动(atrial fibrillation,AF)的急性非ST段抬高型心肌梗死(non-ST-segment elevationmyocardial infarction,NSTEMI)患者的血清galectin-3和高敏C-反应蛋白(high sensitivity C-reactive protein,hs-CRP)浓度与不良预后之间的相关性。方法本研究入组了32例既往有AF病史的NSTEMI患者作为主要研究对象,并以32例无AF的NSTEMI患者做为对照组,进行为期12个月的随访观察,以主要心脑血管不良事件(major adverse cardiac and cerebrovascular events,MACCEs)的发生为随访终点。比较两组患者入院时血清galectin-3和hs-CRP浓度的差异,并通过多因素分析来分析血清galectin-3和hs-CRP浓度对MACCEs发生的预测价值。结果与无AF的患者相比,并发AF患者的血清galectin-3和hs-CRP浓度明显较高,差异有统计学意义[(10.01±2.49)ng/mL vs.(8.57±2.50)ng/mL,P=0.024;(21.66±10.98)mg/L vs.(8.47±3.24)mg/L,P<0.001)]。Galectin-3浓度>7.53 ng/mL的患者发生MACCEs的风险增加8倍(HR=8.056,95%CI:1.880～23.214,P=0.005),而hs-CRP>6.55 mg/L的患者发生MACCEs的风险增加2.5倍(HR=2.531,95%CI:1.392～6.348,P=0.005)。结论并发AF的NSTEMI患者的血清galectin-3和hs-CRP浓度显著升高,galectin-3和hs-CRP浓度升高能够有效预测患者发生MACCEs的风险。
Objectives To investigate the correlation between serum concentrations of galectin-3,high sensitivity Creactive protein(hs-CRP)and prognosis in patients with acute non-ST-segment elevation myocardial infarction(NSTEMI)complicated with atrial fibrillation(AF).Methods This study enrolled32cases of NSTEMI patients with previous AF as the main objects,and another32cases of NSTEMI without AF as a control group.And a12-month followup observation was taken to record the major adverse cardiac and cerebrovascular events(MACCEs)in this study.MACCEs was used as end points of this study.The differences of serum concentrations of galectin-3and hs-CRP between the two groups were compared,and the predictive value of serum concentrations of galectin-3and hs-CRP for MACCEs was analyzed by multivariate analysis.Results Serum concentrations of galectin-3and hs-CRP in NSTEMI patients with AF were significantly higher than those in NSTEMI patients without AF[(10.01±2.49)ng/mL vs.(8.57±2.50)ng/mL,P=0.024;(21.66±10.98)mg/L vs.(8.47±3.24)mg/L,P<0.001)].Patients with concentration of galectin-3>7.53ng/mL had a8-fold increased risk of MACCEs(HR=8.056,95%CI:1.880-23.214,P=0.005)and patients with concentration of hs-CRP>6.55mg/mL had a2.5-fold increased risk of MACCEs(HR=2.531,95%CI:1.392-6.348,P=0.005).Conclusions Serum concentrations of galectin-3and hs-CRP significantly increase in NSTEMI patients with AF,and the increased serum concentrations of galectin-3and hs-CRP could effectively predict the risk of MACCEs.
作者
邢尔克
贾军正
周红娟
XING Er-ke;JIA Jun-zheng;ZHOU Hong-juan(Department of Cardiology,Baoji Traditional Chinese Medicine Hospital,Baoji,Shaanxi 721001,China;Department of Anesthesiology,Baoji Traditional Chinese Medicine Hospital,Baoji,Shaanxi 721001,China)
出处
《岭南心血管病杂志》
2018年第6期651-656,共6页
South China Journal of Cardiovascular Diseases
作者简介
邢尔克(1985-),男,主治医师,研究方向为冠心病、高血压的诊治;通信作者:周红娟,E-mail:zhouhongj19@163.com。
