摘要
目的观察丹参酮ⅡA磺酸钠注射液联合贝那普利治疗冠心病心力衰竭的临床疗效,并分析其对心功能、血液流变学的影响。方法选取2016年7月—2017年8月安庆市立医院收治的冠心病心力衰竭患者74例,采用随机数字表法分为对照组和研究组,每组37例。在常规治疗基础上,对照组患者给予丹参酮ⅡA磺酸钠注射液治疗,研究组患者给予丹参酮ⅡA磺酸钠注射液联合贝那普利治疗;两组患者均连续治疗4周。比较两组患者临床疗效,治疗前后心功能指标[包括左心室射血分数(LVEF)、心排血量(CO)、每搏输出量(SV)及血浆脑钠肽(BNP)水平]、血液流变学指标(包括纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度);并观察两组患者治疗期间不良反应发生情况。结果 (1)研究组患者临床疗效优于对照组(P<0.05)。(2)两组患者治疗前LVEF、CO、SV及血浆BNP水平比较,差异无统计学意义(P>0.05);研究组患者治疗后LVEF高于对照组,CO、SV大于对照组,血浆BNP水平低于对照组(P<0.05)。(3)两组患者治疗前纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度比较,差异无统计学意义(P>0.05);研究组患者治疗后纤维蛋白原、血浆黏度、全血低切黏度及全血高切黏度低于对照组(P<0.05)。(4)两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论丹参酮ⅡA磺酸钠注射液联合贝那普利治疗冠心病心力衰竭效果确切,能有效改善患者心功能及血液流变学,且安全性较高。
Objective To observe the clinical effect of tanshinoneⅡA sodium sulfonate injection combined with benazepril on coronary heart disease-induced heart failure,to analyze the impact on cardiac function and hemorheology.Methods A total of74patients with coronary heart disease-induced heart failure were selected in Anqing Municipal Hospital from July2016to August2017,and they were divided into control group and study group according to random number table,each of37cases.Based on conventional treatment,patients in control group received tanshinoneⅡA sodium sulfonate injection,while patients in study group received tanshinoneⅡA sodium sulfonate injection combined with benazepril;both groups continuously treated for4weeks.Clinical effect,index of cardiac function(including LVEF,CO,SV and plasma BNP level)and hemodynamic index(including fibrinogen,plasma viscosity,whole low-shear blood viscosity and whole highshear blood viscosity)before and after treatment were compared between the two groups,and incidence of adverse reactions was observed during treatment.Results(1)Clinical effect in study group was statistically significantly better than that in control group(P<0.05).(2)No statistically significant differences of LVEF,CO,SV or plasma BNP level was found between the two groups before treatment(P>0.05);after treatment,LVEF in study group was statistically significantly higher than that in control group,CO and SV in study group were statistically significantly larger than those in control group,while plasma BNP level in study group was statistically significantly lower than that in control group(P<0.05).(3)No statistically significant differences of fibrinogen,plasma viscosity,whole low-shear blood viscosity or whole high-shear blood viscosity was found between the two groups before treatment(P>0.05),while fibrinogen,plasma viscosity,whole low-shear blood viscosity and whole high-shear blood viscosity in study group were statistically significantly lower than those in control group after treatment(P<0.05).(4)No statistically significant differences of incidence of adverse reactions was found between the two groups during treatment(P>0.05).Conclusion TanshinoneⅡA sodium sulfonate injection combined with benazepril has certain clinical effect in treating coronary heart disease-induced heart failure,can effectively improve the cardiac function and hemorheology,with relativity high safety.
作者
姜明
乔锐
JIANG Ming;QIAO Rui(Department of Cardiology,Anqing Municipal Hospital,Anqing 246000,China)
出处
《实用心脑肺血管病杂志》
2018年第10期96-99,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
冠心病
心力衰竭
丹参酮ⅡA磺酸钠注射液
贝那普利
心功能
血液流变学
Coronary disease
Heart failure
Tanshinone Ⅱ A sodium sulfonate injection
Benazepril
Cardiac function
Hemorheology
