摘要
目的探讨不同年龄组扩张型心肌病(DCM)患者的临床特点。方法根据发病年龄,将138例DCM患者分为青年组(<45岁,n=35),中年组(45～59岁,n=79),老年组(≥60岁,n=24),以及男(n=114)女(n=24)两组,回顾性分析患者的性别、民族、发病年龄、危险因素(吸烟史、饮酒史)、心功能分级、脑利钠尿肽(BNP)、心脏彩超测量值。结果 (1)三组DCM患者的男女比例、饮酒史、心功能分级、BNP、左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)的差异有统计学意义(P <0.05),而民族、吸烟史、左心室舒张未期内径(LVD)、左心房收缩末期内径(LAS)、肺动脉收缩压(PASP)的差异无统计学意义(P>0.05)。(2)男女平均发病年龄、饮酒史、BNP水平的差异有统计学意义(P <0.05),男女LVD、LAS、LVEF、LVFS、PASP的差异无统计学意义(P>0.05)。结论不同发病年龄的DCM患者的临床指标差异具有指导意义,这为进一步了解DCM临床特点,为做到早发现、早诊断、早干预、早治疗提供理论支持。
Objective To explore the clinical characteristics of patients with dilated cardiomyopathy(DCM)in different age groups. Methods According to age of onset,138 DCM patients were divided into youth group(<45 years old,n =35),middle-aged group(45~59 years old,n =79),elderly group(≥60 years old,n=24),meanwhile,male group(n=114)and female group(n=24).The gender,nationality,age of onset,risk factors(smoking history,drinking history),cardiac function grading,brain natriuretic peptide(BNP)and the measurements of heart color Doppler ultrasonography among different group patients were analyzed retrospectively. Results(1)There were significant differences in male to female ratio,drinking history,cardiac function grading,BNP,left vertricular ejection fraction(LVEF),left ventricular fractional shortening(LVFS)among the three groups of DCM patients(P <0.05),and there was no significant difference in ethnicity,smoking history,left ventricular diastolic end diameter(LVD),left atrial end systolic diameter(LAS)and pulmonary arterial systolic pressure(PASP)among the three DCM groups(P >0.05).(2)There were significant differences in average age of onset,drinking history and BNP level between men and women(P <0.05),and there was no significant difference in LVD,LAS,LVEF,LVFS,PASP between men and women(P>0.05). Conclusion The differences in clinical indicators of DCM patients with different age of onset have guiding significance,which provide theoretical support for further understanding of clinical characteristics of DCM and achieving early detection,diagnosis,intervention and treatment.
作者
黄妹丹
陈宇晴
何凤珍
张文燕
周尚蓉
潘兴寿
刘莉
Huang Meidan;Chen Yuqing;He Fengzhen;Zhang Wenyan;Zhou Shangrong;Pan Xingshou;Liu Li(Graduate School of Youjiang Medical University for Nationalities,Baise533000,Guangxi China;Affiliated Hospital of Youjiang Medical University for Nationalities,Baise533000,Guangxi,China)
出处
《右江民族医学院学报》
2018年第6期533-536,共4页
Journal of Youjiang Medical University for Nationalities
基金
国家自然科学基金地区项目(81560076)
广西高校中青年教师基础能力提升项目(2017KY0514)
2018年研究生创新项目(YCSW2018216)
关键词
心肌病
扩张型
临床特点
脑利钠尿肽
心功能
cardiomyopathy,dilated
clinical features
brain natriuretic peptide
cardiac function
作者简介
第一作者:黄妹丹(1990-),女,在读硕士研究生,研究方向:心血管疾病基础与临床,E-mail:1347289742@qq.com;通信作者:刘莉(1980-),女,博士,讲师,研究方向:心血管疾病分子生物学,E-mail:liuli011258@sina.com.
