摘要
目的探讨重组人干扰素α2a联合利巴韦林治疗慢性丙型肝炎合并脂肪肝的效果。方法选取我院2016年3月～2017年3月收治的76例慢性丙型肝炎合并脂肪肝患者作为研究对象,按照奇偶分组方法分为对照组和实验组,每组各38例。对照组采用利巴韦林治疗,实验组采用重组人干扰素α2a联合利巴韦林治疗,比较两组的病毒载量、HCV-RNA转阴率。结果实验组的慢性丙肝病毒(HCV-RNA)、瘦素含量(LEP)和胰岛素抵抗指数(HOMAIR)均高于对照组,丙氨酸转氨酶(ALT)低于对照组,差异有统计学意义(P<0.05);实验组的HCV-RNA转阴率为68.42%,高于对照组,差异有统计学意义(P<0.05);实验组的病毒载量降低率为78.95%,高于对照组,差异有统计学意义(P<0.05)。结论慢性丙肝合并脂肪肝患者接受重组人干扰素α2a联合利巴韦林治疗,能起到改善患者病情的作用,能调节肝脏脂代谢,起到抗病毒的效果,值得推广应用。
Objective To investigate the effect of recombinant human interferonα2a combined with Ribavirin in the treatment of chronic hepatitis C with fatty liver.Methods Seventy-six patients with chronic hepatitis C complicated with fatty liver admitted to our hospital from March2016to March2017were enrolled.The participants were divided into control group(n=38)and experimental group(n=38)according to the odd/even number.In the control group,Ribavirin was used,while in the experimental group,recombinant human interferonα2a combined with Ribavirin was adopted.The viral load and hepatitis C virus-RNA(HCV-RNA)negative conversion rate were compared between the two groups.Results The chronic HCV-RNA,leptin content(LEP)and homeostasis model assessment of insulin resistance(HOMA-IR)were higher in the experimental group than in the control group,and alanine aminotransferase(ALT)was lower than the control group with statistical significance(P<0.05).In the experimental group,the HCV-RNA negative conversion rate was68.42%,higher than that of the control group with a significant difference(P<0.05).The reduction rate of viral load in the experimental group was78.95%,higher than that of the control group with a statistical difference(P<0.05).Conclusion Application of recombinant human interferonα2a combined with Ribavirin in the treatment of patients with chronic hepatitis C complicated with fatty liver can improve the patient′s condition,regulate liver lipid metabolism,and exert on antiviral effect,which is worthy of wide promotion.
作者
靳镝
JIN Di(Fushun Infectious Disease Hospital, Liaoning Province, Fushun 113006, China)
出处
《中国当代医药》
2018年第33期59-61,共3页
China Modern Medicine
关键词
抗病毒
慢性丙肝
脂肪肝
Antiviral
Chronic hepatitis C
Fatty liver
