摘要
轮状病毒(Rotavirus,RV)是引起婴幼儿及幼龄动物急性腹泻甚至死亡的重要病原。2009年,首次在幼龄大熊猫粪便中分离到RV,被确定为A组,并将其命名为大熊猫轮状病毒(Giant Panda Rotavirus,GPRV)CH-1株。GPRV CH-1株主要感染断奶后的大熊猫,引起急性传染性、顽固性腹泻甚至死亡,这对大熊猫的健康造成了严重的危害。本文介绍了GPRV CH-1株的基因结构和病毒蛋白结构及其生物信息学分析学以及该病的诊断方法和防治措施,以期为该病致病机制及疫苗研究提供参考。
Rotavirus is the most important cause of severe diarrhea and death in infants and young animals.In 2009,rotavirus was isolated from fecal samples of sick panda cubs suffered an acute,infectious and intractable diarrhea.The strain belongs to group A and is designated as Giant Panda Rotavirus(GPRV)strain CH-1,which has caused serious threats to giant panda.In this paper,we review the gene structure,viral proteins,bioinformatics analysis of GPRV strain CH-1,and the diagnostic methods and prophylactico-therapeutic measures of this disease.This review will be helpful for further study of the pathogenic mechanism,as well as vaccine development of GPRV strain CH-1.
作者
杨锐
王成东
颜其贵
YANG Rui;WANG Cheng-dong;YAN Qi-gui(College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,China;Chengdu Research Base of Giant Panda Breeding,Chengdu 610081,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2018年第11期1040-1043,共4页
Chinese Journal of Zoonoses
基金
成都大熊猫繁育研究基金会科研项目(No.CPF08013)~~
作者简介
通讯作者:颜其贵,Email:yanqigui@126.com。
