摘要
AIM To evaluate the relationship between the state of transplanted liver graft and the recipient quality of life(QOL)of histologically proven lesions in a 10-year post liver transplantation(LT)cohort of patients.METHODS Seventy-two recipients with a functional first graft at 10 years post-LT underwent liver biopsy and completed a QOL questionnaire.Logistic regression analysis was used to explore associations between histological,clinical andQOL criteria.RESULTS Ten years after LT,fibrosis was detected in 53%of patients,and affected the general health perception,while ductopenia,present in 36%,affected the well-being(P=0.05).Hepatic steatosis(HS)was present in 33%of patients and was associated with the worst QOL score on multiple domains.When compared to patients without HS,patients with HS had significantly higher incidence of fibrosis(P=0.03),hepatitis C virus(HCV)infection(P=0.007),and more patients had retired from their job(P=0.03).Recurrent or de novo HCV-associated fibrosis and patient retirement as objective variables,and abdominal pain or discomfort and joint aches or pains as subjective variables,emerged as independent determinants of HS.CONCLUSION Long-term liver graft lesions,mainly HS presumably as a surrogate marker of HCV infection,may have a substantial impact on QOL 10 years after LT.
作者简介
Correspondence to:Vincent Karam,PhD,Centre Hépatobiliaire,Assistance Publique-H?pitaux de Paris,UniversitéParis-Sud,Hepital Paul Brousse,12-14,Avenue Paul Vaillant Couturier,B.P.200,F-94804 Villejuif,France.vincent.karam-ext@aphp.fr Telephone:+33-1-45593437 Fax:+33-1-45593437.
